Curriculum vitae

Main Research Areas
  • Infection biology of human pathogenic fungi (Candida albicans)
  • Immunology of fungal infections
  • Host-pathogen interactions
  • Fungal adaptation to the host
Professional Career
Since
05/2020
Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies
05/2018-
05/2020
Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms
03/2018-04/2018 Language Course German, Dresden, Germany
08/2015-03/2018 Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015 Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010 M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands
07/2003-07/2007 B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands
Awards · Appointments · Scientific Activities
2021 Research award of the German speaking society for Mycology (DMykG)
2021 Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena
Since 2021 Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2020 DFG Emmy Noether grant
2020 Journal of Fungi Travel Award
2020 Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany
2019 PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens
2019 ESCMID Research Grant 2019
2019 Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network
2018-2021 Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author)
2018 Humboldt Research Fellowship for Postdoctoral Researchers
2018 Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center
2016 3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)
2015 Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI)
2015 Youth development Prize by the German speaking society for Mycology (DMykG)
Since 2014 Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others
2013 ALLFUN Investigators Award

Publications

Alonso-Roman R, Mosig AS, Figge MT, Papenfort K, Eggeling C, Schacher FH, Hube B, Gresnigt MS (2024) Organ-on-chip models for infectious disease research. Nat Microbiol ,
Jaeger M, Dietschmann A, Austermeier S, Dinçer S, Porschitz P, Vornholz L, Maas RJA, Sprenkeler EGG, Ruland J, Wirtz S, Azam T, Joosten LAB, Hube B, Netea MG, Dinarello CA, Gresnigt MS (2024) Alpha1-antitrypsin impacts innate host-pathogen interactions with Candida albicans by stimulating fungal filamentation. Virulence , 2333367.
Kaden T, Alonso-Roman R, Akbarimoghaddam P, Mosig AS, Graf K, Raasch M, Hoffmann B, Figge MT, Hube B, Gresnigt MS (2024) Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity. Biomaterials 307, 122525.
Schimanski J, Gresnigt MS, Brunner E, Werz O, Hube B, Garscha U (2024) Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells. Eur J Immunol 54(3), e2350743.
Valentine M*, Rudolph P*, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS*#, Hube B*# (2024) Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis. mBio 15(3), e0340923.
Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE (2023) Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation. Nat Immunol 24(2), 295-308.
Lange T, Kasper L, Gresnigt MS, Brunke S, Hube B (2023) "Under Pressure" - How fungi evade, exploit, and modulate cells of the innate immune system. Semin Immunol 66, 101738. (Review)
Alonso-Roman R, Last A, Mirhakkak MH, Sprague JL, Möller L, Großmann P, Graf K, Gratz R, Mogavero S, Vylkova S, Panagiotou G, Schäuble S, Hube B, Gresnigt MS (2022) Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity. Nat Commun 13(1), 3192.
Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V (2022) Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis. Redox Biol 55, 102391.
Pekmezovic M, Dietschmann A, Gresnigt MS (2022) Type I interferons during host-fungus interactions: Is antifungal immunity going viral? PLOS Pathog 18(8), e1010740.

News