Freddy Alexander Bernal

PhD Freddy Alexander Bernal

Transfer Group Anti-infectives +49 3641 532-1044 freddy.bernal@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Computer-Aided Drug Discovery
  • Organic Synthesis of Drug-like Antimicrobial Compounds
Professional Career
Since 09.2020 Chemist for Drug Discovery, Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI), Jena, Germany. Topic: Computer-aided discovery and optimization of novel antimicrobials.
08.2015-10.2019 Doctorate (Doctor of Natural Sciences – Pharmacy), Westfälische Wilhelms – Universität Münster, Münster, Germany. Dissertation title: Qualitative and quantitative structure-activity relationships on 2-phenyl-2,3-dihydrobenzofurans as Leishmanicidal agents. Research advisor: Prof. Dr. Thomas J. Schmidt
02.2012-05.2015 Research Assistant. Bioorganic Chemistry, Military University Nueva Granada, Cajicá, Colombia.
07.2011-05.2015 Lecturer, General Chemistry. Department of Chemistry, Military University Nueva Granada, Bogotá, Colombia.
08.2011-12.2013 Lecturer, Instrumental Analysis and Spectroscopy. Department of Educational Chemistry, Distrital University Francisco Jose de Caldas, Bogotá, Colombia.
02.2010-12.2010 Lecturer, Organic Chemistry and Analytical Chemistry. Technological Corporation of Bogota, Bogotá, Colombia.
08.2007-10.2009 Master in Sciences – Chemistry, National University of Colombia, Bogotá, Colombia. Thesis title: Isolation of secondary metabolites from the leaves of Iryanthera ulei Warb. (Myristicaceae), evaluation of their antimicrobial activity and synthesis of one 8-O-4′-neolignan. Research advisor: Prof. Dr. Luis E. Cuca.
02.2002-02.2007 Bachelor in Chemistry, National University of Colombia, Bogotá, Colombia.

Publications

Bernal FA, Orduz-Diaz LL, Coy-Barrera ED (2016) Application of PARAFAC and OPLS-DA analyses on HPLC fingerprints for the characterization of Hibiscus sabdariffa calyxes. Quim. Nova 39(2), 160-166.
Bernal FA, Orduz-Diaz LL, Guerrero-Perilla C, Coy-Barrera ED (2016) Diazo coupling reaction of catechins and alkylresorcinols with diazotized sulfanilic acid for quantitative purposes in edible sources: method development and validation. Food Analytical Methods 9(2), 411-418.
Bernal FA, Coy-Barrera E (2015) Molecular docking and multivariate analysis of xanthones as antimicrobial and antiviral agents. Molecules 20(7), 13165-13204.
Bernal FA, Coy-Barrera ED (2015) Chemical profile and antioxidant capacity of calyxes from commercial crops-derived Colombian Roselle (Hibiscus sabdariffa L.). Medicinal Plants - International Journal of Phytomedicines and Related Industries 7(2), 137-144.
Bernal FA, Cuca LE, Fadini L (2015) A Facile approach toward 8-O-4'-neolignans: synthesis of threo-7',8'-dihydromachilin D through Jacobsen epoxidation Revista Facultad de Ciencias Básicas 11(1), 114-129.
Bernal FA, Orduz-Diaz LL, Coy-Barrera E (2015) Exploitation of the complexation reaction of ortho-dihydroxylated anthocyanins with aluminum(III) for their quantitative spectrophotometric determination in edible sources. Food Chem 185, 84-89.
Bernal FA, Coy-Barrera E (2014) In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets. Molecules 19(5), 5550-5569.
Orduz-Diaz LL, Bernal FA, Coy-Barrera ED (2014) Diterpenos de núcleo kaurano como inhibidores de la PTR1 de Leishmania: un estudio in silico. Revista Facultad de Ciencias Básicas 9(1), 142-152.
Bernal FA, Cuca-Suárez LE, Yamaguchi LF, Coy-Barrera ED (2013) LC-DAD-UV and LC-ESI-MS-based analyses, antioxidant capacity, and antimicrobial activity of a polar fraction from Iryanthera ulei leaves. Records of Natural Products 7(2), 152-156.
Bernal FA, Delgado WA, Cuca LE (2012) Fingerprint analysis of unfractionated piper plant extracts by HPLC-UV-DAD coupled with chemometric methods. Journal of the Chilean Chemical Society 57(3), 1256-1261.