(2024)
Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology.
Front Hematol 3,
Publications
(2024)
Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity.
Front Immunol 15,
1383123.
(2022)
Novel FHR2 variants in atypical haemolytic uremic syndrome: a case study of translational medicine approach in renal transplantation.
Front Immunol 13,
1008294.
(2020)
A genome-wide association study identifies key modulators of complement factor h binding to malondialdehyde-epitopes.
Proc Nat Acad Sci USA 117(18),
9942-9951.
(2019)
C3-glomerulopathy autoantibodies mediate distinct effects on complement C3- and C5-convertases.
Front Immunol 10,
1030.
(2018)
The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.
Mol Immunol 93,
266-277.
(2018)
FHR5 binds to laminins, uses separate C3b and surface-binding sites, and activates complement on malondialdehyde-acetaldehyde surfaces.
J Immunol 200(7),
2280-2290.
(2016)
Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.
J Am Soc Nephrol 27(5),
1413-1425.
(2014)
Complement factor H-related hybrid protein deregulates complement in dense deposit disease.
J Clin Invest 124(1),
145-155.
(2013)
Human factor H-related protein 2 (CFHR2) regulates complement activation.
PLOS One 8(11),
e78617.