Publications

Perie L*, Stippa S*, Saffer C*, Hartmann A, Mörglin M, Zipfel SLH, Figge MT, Wiech T, Skerka C, Zipfel PF# (2024) Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology. Front Hematol 3,
Tschongov T, Konwar S, Busch A, Sievert C, Hartmann A, Noris M, Gastoldi S, Aiello S, Schaaf A, Panse J, Zipfel PF, Dabrowska-Schlepp P, Häffner K (2024) Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity. Front Immunol 15, 1383123.
Stea ED, Skerka C, Accetturo M, Pesce F, Wiech T, Hartmann A, Pontrelli P, Castellano G, Zipfel PF, Gesualdo L (2022) Novel FHR2 variants in atypical haemolytic uremic syndrome: a case study of translational medicine approach in renal transplantation. Front Immunol 13, 1008294.
Alic L, Papac-Milicevic N, Czamara D, Rudnick RB, Ozsvar-Kozma M, Hartmann A, Gurbisz M, Hoermann G, Haslinger-Hutter S, Zipfel PF, Skerka C, Binder EB, Binder CJ (2020) A genome-wide association study identifies key modulators of complement factor h binding to malondialdehyde-epitopes. Proc Nat Acad Sci USA 117(18), 9942-9951.
Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C (2019) C3-glomerulopathy autoantibodies mediate distinct effects on complement C3- and C5-convertases. Front Immunol 10, 1030.
Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277.
Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF (2018) FHR5 binds to laminins, uses separate C3b and surface-binding sites, and activates complement on malondialdehyde-acetaldehyde surfaces. J Immunol 200(7), 2280-2290.
Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF (2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425.
Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155.
Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C (2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617.