(2024)
Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway.
Angew Chem Int Ed 63(30),
e202405165.
Publications
(2023)
Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis.
ACS Chem Biol 18(7),
1557-1563.
(2022)
Sequential allylic alcohol formation by a multifunctional cytochrome P450 monooxygenase with rare redox partners.
Angew Chem Int Ed 61(26),
e202203264.
(2022)
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat Chem 14(8),
884-890.
(2020)
Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor.
Angew Chem Int Ed 59(32),
13511-13515.
(2019)
Genomics-driven discovery of NO-donating diazeniumdiolate siderophores in diverse plant-associated bacteria.
Angew Chem Int Ed 58(37),
13024-13029.
(2019)
Biosynthesis of diverse antimicrobial and antiproliferative acyloins in anaerobic bacteria.
ACS Chem Biol 14(7),
1490-1497.
(2017)
Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun 8,
15804.
(2016)
Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme.
Angew Chem Int Ed 55(39),
11955-11959.
(2010)
Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum.
Angew Chem Int Ed Engl 49(11),
2011-2013.
