Dr. Daniel H. Scharf



Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM (2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed 53(8), 2221-2224.
Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C (2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679.
Scharf DH, Heinekamp T, Brakhage AA (2014) Human and plant fungal pathogens: the role of secondary metabolites. PLOS Pathog 10(1), e1003859. (Review)
Knop K, Pavlov GM, Rudolph T, Martin K, Pretzel D, Jahn BO, Scharf DH, Brakhage AA, Makarov V, Möllmann U, Schacher FH, Schubert US (2013) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: Investigations using a novel fungicide. Soft Matter 3(9), 715-726.
Knop K, Pretzel D, Urbanek A, Rudolph T, Scharf DH, Schallon A, Wagner M, Schubert S, Kiehntopf M, Brakhage AA, Schacher FH, Schubert US (2013) Star-shaped drug carriers for doxorubicin with POEGMA and POEtOxMA brush-like shells: A structural, physical, and biological comparison. Biomacromolecules 14(8), 2536-2548.
Scharf DH, Brakhage AA (2013) Engineering fungal secondary metabolism: A roadmap to novel compounds. J Biotechnol 163(2), 179-183. (Review)
Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C (2013) Epidithiodiketopiperazine biosynthesis: A four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed 52(42), 11092-11095.
Huber EM, Scharf DH, Hortschansky P, Groll M, Brakhage AA (2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10), 1757-1768.
Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed 51(40), 10064-10068.
Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C (2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472.