(2018)
Reconstitution of enzymatic carbon-sulfur bond formation reveals detoxification-like strategy in fungal toxin biosynthesis.
ACS Chem Biol 13(9),
2508-2512.
Prof. Dr. Christian Hertweck
Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.deCurriculum vitae
Main Research Areas
- Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
- Use of enzymes and recombinant microorganisms for synthetic implementation
- Isolation and structural identification of natural products
- Molecular basis of fungus-bacteria-interactions
Professional Career
| 2008 | Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland |
| 2008 – 2023 | Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany |
| 2008 | Rejection of professorship, Technical University Munich, Germany |
| Since 2006 | Head of Department of Biomolecular Chemistry, HKI Jena |
| Since 2006 | Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany |
| 2006 | Habilitation (Venia legendi) in organic chemistry, FSU Jena |
| 2005 | Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany |
| 2005 | Acceptance of professorship (W3), FSU Jena |
| 2001– 2005 | Head of junior research group, HKI Jena |
| 1999 – 2000 | Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation) |
| 1996 – 1999 | PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship |
| 1996 | Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany |
Awards · Appointments · Scientific Activities
| 2015 | Member of the National Academy of Sciences Leopoldina |
| 2015 | Gottfried Wilhelm Leibniz Award |
| 2015 | David Gottlieb Memorial Lecture Award, University of Illinois |
| 2014 | Wilhelm Manchot-Research Professor |
| Since 2013 | Member of the editorial board Bioorganic Chemistry |
| Since 2012 | Editor, Chemistry & Biology |
| Since 2012 | Member of the faculty of 1000 |
| Since 2011 | Member of the editorial board, Organic and Biomolecular Chemistry |
| Since 2011 | Member of the editorial board, Journal of Antibiotics |
| 2011 | NPR lecture award |
| Since 2010 | Member of the editorial board, ChemBioChem |
| 2009 – 2012 | Member of the editorial board, Chemistry & Biology |
| 2006 | Research prize of the Dr. Otto Röhm-Memorial-Foundation |
| Since 2005 | Member of the Association for General and Applied Microbiology (VAAM) |
| 2005 | DECHEMA award for natural product research |
| 2005 | Science award for life sciences and physics from the Beutenberg Campus Jena e.V. |
| 2005 | Thuringian research award (category: basic research) |
| Since 2003 | Member of the programme committee, Natural Product Meeting, Irsee |
| Since 2002 | Member of the DECHEMA Society for Chemical Engineering and Biotechnology |
| Since 2001 | Member of the Gesellschaft Deutscher Chemiker (GDCh) |
Publications
(2018)
Mediators of mutualistic microbe-microbe interactions.
Nat Prod Rep 35(4),
303-308.
(Review)
(2018)
On-line polyketide cyclization into diverse medium-sized lactones by a specialized ketosynthase domain.
Angew Chem Int Ed 57(35),
11223-11227.
(2018)
Two types of threonine-tagged lipopeptides synergize in host colonization by pathogenic Burkholderia species.
ACS Chem Biol 13(5),
1370-1379.
(2018)
Enzymatic amide tailoring expedites unusual retro-aldol-type amino acid conversion to form antifungal cyclopeptide.
Angew Chem Int Ed 57(43),
14051-14054.
(2017)
Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells.
Nat Commun 8(1),
1756.
(2017)
A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore.
Appl Environ Microbiol 83(21),
e01478.
(2017)
Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase.
Angew Chem Int Ed 56(21),
5937-5941.
(2017)
Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis.
Chem Rev 117(8),
5521-5577.
(Review)
(2017)
Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism.
Nat Commun 8,
15172.
