Christian Hertweck

Prof. Dr. Christian Hertweck

Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
  • Use of enzymes and recombinant microorganisms for synthetic implementation
  • Isolation and structural identification of natural products
  • Molecular basis of fungus-bacteria-interactions
Professional Career
2008 Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland
2008 – 2023 Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany
2008 Rejection of professorship, Technical University Munich, Germany
Since 2006 Head of Department of Biomolecular Chemistry, HKI Jena
Since 2006 Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany
2006 Habilitation (Venia legendi) in organic chemistry, FSU Jena
2005 Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany
2005 Acceptance of professorship (W3), FSU Jena
2001– 2005 Head of junior research group, HKI Jena
1999 – 2000 Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation)
1996 – 1999 PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship
1996 Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany
Awards · Appointments · Scientific Activities
2015 Member of the National Academy of Sciences Leopoldina
2015 Gottfried Wilhelm Leibniz Award
2015 David Gottlieb Memorial Lecture Award, University of Illinois
2014 Wilhelm Manchot-Research Professor
Since 2013 Member of the editorial board Bioorganic Chemistry
Since 2012 Editor, Chemistry & Biology
Since 2012 Member of the faculty of 1000
Since 2011 Member of the editorial board, Organic and Biomolecular Chemistry
Since 2011 Member of the editorial board, Journal of Antibiotics
2011 NPR lecture award
Since 2010 Member of the editorial board, ChemBioChem
2009 – 2012 Member of the editorial board, Chemistry & Biology
2006 Research prize of the Dr. Otto Röhm-Memorial-Foundation
Since 2005 Member of the Association for General and Applied Microbiology (VAAM)
2005 DECHEMA award for natural product research
2005 Science award for life sciences and physics from the Beutenberg Campus Jena e.V.
2005 Thuringian research award (category: basic research)
Since 2003 Member of the programme committee, Natural Product Meeting, Irsee
Since 2002 Member of the DECHEMA Society for Chemical Engineering and Biotechnology
Since 2001 Member of the Gesellschaft Deutscher Chemiker (GDCh)

Topics

Publications

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162.
Details
PubMed
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631.
Details
PubMed Open Access
Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674.
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PubMed
Sugimoto Y, Ishida K, Traitcheva N, Busch B, Dahse HM, Hertweck C (2015) Freedom and constraint in engineered noncolinear polyketide assembly lines Chem Biol 22(2), 229-240.
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PubMed
Sundaram S, Heine D, Hertweck C (2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching Nat Chem Biol. 11(12), 949-951.
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PubMed
Uzum Z, Silipo A, Lackner G, De Felice A, Molinaro A, Hertweck C (2015) Structure, Genetics and Function of an Exopolysaccharide Produced by a Bacterium Living within Fungal Hyphae. Chembiochem 16(3), 387-392.
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PubMed
Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle TF, Stehle T (2015) Structural basis of head to head polyketide fusion by CorB. Chem Sci 6(11), 6525-6536.
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Cai X, Ng K, Panesar H, Moon SJ, Paredes M, Ishida K, Hertweck C, Minehan TG (2014) Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile. Org Lett 16(11), 2962-2965.
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PubMed
Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413.
Details
PubMed
Coyne S, Litomska A, Chizzali C, Khalil MN, Richter K, Beerhues L, Hertweck C (2014) Control of plant defense mechanisms and fire blight pathogenesis through the regulation of 6-thioguanine biosynthesis in Erwinia amylovora. Chembiochem 15(3), 373-376.
Details
PubMed

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