(2011)
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.
Mol Microbiol 82(1),
39-53.
Prof. Dr. Christian Hertweck
Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.deCurriculum vitae
Main Research Areas
- Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
- Use of enzymes and recombinant microorganisms for synthetic implementation
- Isolation and structural identification of natural products
- Molecular basis of fungus-bacteria-interactions
Professional Career
| 2008 | Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland |
| 2008 – 2023 | Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany |
| 2008 | Rejection of professorship, Technical University Munich, Germany |
| Since 2006 | Head of Department of Biomolecular Chemistry, HKI Jena |
| Since 2006 | Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany |
| 2006 | Habilitation (Venia legendi) in organic chemistry, FSU Jena |
| 2005 | Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany |
| 2005 | Acceptance of professorship (W3), FSU Jena |
| 2001– 2005 | Head of junior research group, HKI Jena |
| 1999 – 2000 | Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation) |
| 1996 – 1999 | PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship |
| 1996 | Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany |
Awards · Appointments · Scientific Activities
| 2015 | Member of the National Academy of Sciences Leopoldina |
| 2015 | Gottfried Wilhelm Leibniz Award |
| 2015 | David Gottlieb Memorial Lecture Award, University of Illinois |
| 2014 | Wilhelm Manchot-Research Professor |
| Since 2013 | Member of the editorial board Bioorganic Chemistry |
| Since 2012 | Editor, Chemistry & Biology |
| Since 2012 | Member of the faculty of 1000 |
| Since 2011 | Member of the editorial board, Organic and Biomolecular Chemistry |
| Since 2011 | Member of the editorial board, Journal of Antibiotics |
| 2011 | NPR lecture award |
| Since 2010 | Member of the editorial board, ChemBioChem |
| 2009 – 2012 | Member of the editorial board, Chemistry & Biology |
| 2006 | Research prize of the Dr. Otto Röhm-Memorial-Foundation |
| Since 2005 | Member of the Association for General and Applied Microbiology (VAAM) |
| 2005 | DECHEMA award for natural product research |
| 2005 | Science award for life sciences and physics from the Beutenberg Campus Jena e.V. |
| 2005 | Thuringian research award (category: basic research) |
| Since 2003 | Member of the programme committee, Natural Product Meeting, Irsee |
| Since 2002 | Member of the DECHEMA Society for Chemical Engineering and Biotechnology |
| Since 2001 | Member of the Gesellschaft Deutscher Chemiker (GDCh) |
Publications
(2011)
Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line.
Chembiochem 12(15),
2284-2288.
(2011)
Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives.
ChemMedChem 6(11),
1998-2001.
(2011)
Impact of endofungal bacteria on infection biology, food safety, and drug development.
PLOS Pathog 7(6),
e1002096.
(2011)
Endofungal bacterium controls its host by an hrp type III secretion system.
ISME J 5(2),
252-261.
(2011)
Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus.
J Bacteriol 193(3),
783-784.
(2011)
Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome.
BMC Genomics 12,
210.
(2011)
A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme.
Environ Microbiol Rep 3(5),
550-558.
(2011)
Farinamycin, a quinazoline from Streptomyces griseus.
J Nat Prod 74(10),
2265-2268.
(2011)
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.
Proc Natl Acad Sci U S A 108(34),
14282-14287.
