(2022) S‐Adenosylmethionine (SAM)-dependent methyltransferase MftM is responsible for methylation of the redox cofactor mycofactocin. ACS Chem Biol 17(11), 3207-3217.
|2016 -today||Junior Group Leader|
|2014 - 2016||PostDoc (Feodor Lynen Research Fellowship)
ETH Zurich (Jörn Piel)
Research focus: Genomics of uncultured natural product producers, biosynthesis of ribosomally produced small molecules
|2011 - 2014||PostDoc
FSU Jena (Dirk Hoffmeister)
Research focus: Polyketide and nonribosomal peptide biosynthesis in mushrooms.
|2006 - 2011||PhD student
HKI Jena (Christian Hertweck)
Research focus: Genomics of natural product-producing bacterial endosymbionts of fungi.
|2001 - 2006||Studies of Biochemistry
(2022) Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F420 and its derivative 3PG-F420. mBio 13(1), e03501-21.
(2022) High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space. Metab Eng 73, 158-167.
(2021) Comparative genomic and metabolic analysis of Streptomyces sp. RB110 morphotypes illuminates genomic rearrangements and formation of a new 46-membered antimicrobial macrolide. ACS Chem Biol 16(8), 1482-1492.
(2020) Biosynthesis of the redox coenzyme F420 in Thermomicrobia involves reduction by standalone nitroreductase superfamily enzymes. Appl Environ Microbiol 86(12), e00457-20.
(2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454.
(2020) Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. Chem Sci 11, 5182-5190.
(2020) Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation. Front Bioeng Biotechnol 8(1399), 593781.
(2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem Biol 14(9), 2088-2094.
(2019) Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. Chem Sci 10(48), 10979-10990.