Publications

Fiedler J, Trottmann F, Ishida K, Mie II, Hertweck C (2024) Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway. Angew Chem Int Ed 63(30), e202405165.
Ishida K, Litomska A, Dunbar KL, Hertweck C (2024) An enzymatic prodrug-like route to thio and selenoamides. Angew Chem Int Ed 63(31), e202404243.
Herisse M, Ishida K, Staiger-Creed J, Judd L, Williams SJ, Howden BP, Stinear TP, Dahse HM, Voigt K, Hertweck C, Pidot SJ (2023) Discovery and biosynthesis of the cytotoxic polyene terpenomycin in human pathogenic Nocardia. ACS Chem Biol 18(8), 1872-1879.
Trottmann F, Fiedler J, Ishida K, Ishida-Ito M, Little RF, Hertweck C (2023) Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis. ACS Chem Biol 18(7), 1557-1563.
Bredy F, Ishida K, Hertweck C (2022) A type III polyketide synthase specific for sporulating negativicutes is responsible for alkylpyrone biosynthesis. ChemBioChem 23(21), e202200431.
Kim HJ, Ishida K, Hertweck C (2022) Thiotemplated biosynthesis of bacterial polyyne fatty acids by a designated desaturase triad. ChemBioChem 23(21), e202200430.
Kim HJ, Ishida K, Ishida-Ito M, Hertweck C (2022) Sequential allylic alcohol formation by a multifunctional cytochrome P450 monooxygenase with rare redox partners. Angew Chem Int Ed 61(26), e202203264.
Krumbholz J, Ishida K, Baunach M, Teikari JE, Rose MM, Sasso S, Hertweck C, Dittmann E (2022) Deciphering chemical mediators regulating specialized metabolism in a symbiotic cyanobacterium. Angew Chem Int Ed 61(26), e202204545.
Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C (2022) Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat Chem 14(8), 884-890.
Ishida K, Shabuer G, Schieferdecker S, Pidot SJ, Stinear TP, Knuepfer U, Cyrulies M, Hertweck C (2020) Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins. Chem Eur J 26(58), 13147-13151.