(2024)
Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway.
Angew Chem Int Ed 63(30),
e202405165.
Publications
(2024)
An enzymatic prodrug-like route to thio and selenoamides.
Angew Chem Int Ed 63(31),
e202404243.
(2023)
Discovery and biosynthesis of the cytotoxic polyene terpenomycin in human pathogenic Nocardia.
ACS Chem Biol 18(8),
1872-1879.
(2023)
Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis.
ACS Chem Biol 18(7),
1557-1563.
(2022)
A type III polyketide synthase specific for sporulating negativicutes is responsible for alkylpyrone biosynthesis.
ChemBioChem 23(21),
e202200431.
(2022)
Thiotemplated biosynthesis of bacterial polyyne fatty acids by a designated desaturase triad.
ChemBioChem 23(21),
e202200430.
(2022)
Sequential allylic alcohol formation by a multifunctional cytochrome P450 monooxygenase with rare redox partners.
Angew Chem Int Ed 61(26),
e202203264.
(2022)
Deciphering chemical mediators regulating specialized metabolism in a symbiotic cyanobacterium.
Angew Chem Int Ed 61(26),
e202204545.
(2022)
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat Chem 14(8),
884-890.
(2020)
Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins.
Chem Eur J 26(58),
13147-13151.