Dr. Sandra Höfgen

Alumni

Publications

Jojić K*, Gherlone F*, Cseresnyés Z, Bissell AU, Hoefgen S, Hoffmann S, Huang Y, Janevska S, Figge MT, Valiante V (2024) The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism. mBio [In press]
Bissell AU, Rautschek J, Hoefgen S, Raguž L, Mattern DJ, Saeed N, Janevska S, Jojić K, Huang Y, Kufs JE, Herboeck B, Guo H, Hillmann F, Beemelmanns C, Valiante V (2022) Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor. ACS Chem Biol 17(2), 386-394.
Hoefgen S, Bissell AU, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022) Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition. Microbiol Spectr 10(5), e0133122.
Maehler D, Hoefgen S, Münchberg U, Schmitz OJ, Rautschek J, Huang Y, Freier E, Valiante V (2022) Time-resolved multiparameter analytics on a cell-free production platform for acyl-CoA precursors. Anal Sci Adv 3, 289-296.
Huang Y, Höfgen S, Valiante V (2021) Biosynthesis of fungal drimane-type sesquiterpene esters. Angew Chem Int Ed 60(44), 23763-23770.
Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P (2020) The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res 48(7), 3567-3590.
Janevska S, Ferling I, Jojić K, Rautschek J, Hoefgen S, Proctor RH, Hillmann F, Valiante V (2020) Self-protection against the sphingolipid biosynthesis inhibitor fumonisin B1 is conferred by a FUM cluster-encoded ceramide synthase. mBio 11(3), e00455-20.
Köhler T, Heida T, Hoefgen S, Weigel N, Valiante V, Thiele J (2020) Cell-free protein synthesis and in situ immobilization of deGFP-MatB in polymer microgels for malonate-to-malonyl CoA conversion. RSC Adv 10, 40588-40596.
Krishnan BP, Prieto-Lopez LO, Hoefgen S, Xue L, Wang S, Valiante V, Cui J (2020) A thermo-magneto-responsive smart biocatalyst for malonyl Coenzyme A synthesis. ACS Appl Mater Interfaces 12(18), 20982-20990.
Kufs JE, Hoefgen S, Rautschek J, Bissell AU, Graf C, Fiedler J, Braga D, Regestein L, Rosenbaum MA, Thiele J, Valiante V (2020) Rational design of flavonoid production routes using combinatorial and precursor-directed biosynthesis. ACS Synth Biol 9(7), 1823-1832.