Curriculum vitae

Main Research Areas
  • Infection biology of human pathogenic fungi (Candida albicans, C. glabrata)
  • Host-/pathogen-interactions
  • Functional genomics and micro-evolution
  • Infection-associated genes
Professional Career
Since 2007 Head, Dept. Microbial Pathogenicity Mechanisms, HKI Jena
Since 2006 Professor (W3), Chair in Microbial Pathogenicity, FSU Jena
2006-2007 Head of the division FG16 “Mycology”, RKI Berlin
2000-2006 Lecturer in Microbiology, FU Berlin
2000-2006 Head of a research group, RKI Berlin
2000 Habilitation in Molecular Microbiology, University of Hamburg
1996-2000 Assistant Professor (C1), Applied Molecular Biology, University of Hamburg
1995-1996 Research Assistant, Applied Molecular Biology, University of Hamburg
1992-1995 Honour Research Fellow, EG- and DFG-funded, University of Aberdeen, United Kingdom
1991 Dr. rer. nat. in Microbiology, University of Göttingen
1986 Diploma in Biology, University of Göttingen, Germany
Awards · Appointments · Scientific Activities

Since 2019

Coordinator RA B Excellence Cluster “Balance of the Microverse” of the FSU
Since 2019 Member and Training Manager of the EU Marie Skłodowska-Curie Innovative Training Network (MC-ITN) “Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections – FunHoMic”
2018-2020 Member of the Review Board (Fachkolleg 204) of the Deutsche Forschungsgemeinschaft, (DFG) 204 (Microbiology, Virology and Immunology)
2018 Member of the International Scientific Committee for the 20th Congress of the International Society for Human and Animal Mycology (ISHAM) 30 June - 4 July 2018 Amsterdam
2017-2019 Speaker and PI of Leibniz Campus “InfectoOptics - Combating infectious diseases with advanced optical methods”
2017 “Drug of the Year” Award of the Leibniz Association
Since 2015 Executive board member of the Centre for Innovation Competence (ZIK) Septomics
2015-2019 Member of the EU MC-ITN “From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts – OPATHY”
2015-2018 Eight publication awards of the DMykG (Co- and Senior author)
2015-2018 Coordinator and PI of Infect-ERA Consortium “FunComPath”: From colonization to infection: dissection of the commensal-to-pathogen shift of Candida albicans
2014-2016 Member of the program committee ASM Candida and candidiasis meeting
2014 Main award (Hauptpreis) of DGHM
Since 2013 Member and Steering Committee of the Leibniz Research Alliance INFECTIONS'21/INFECTIONS
Since 2013 Member, PI and Steering Committee of DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2013 Organiser & Co-Organizer of FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” (2013, 2016 and 2020) in Jena, Germany
2013-2017 Member of “International Project Advisory Board” of the Belgian network “MICRODEV – Role of developmental processes in the virulence of human pathogens: from molecular mechanisms to novel therapeutic targets”
Since 2013 Honorary member of Deutschsprachige Mykologische Gesellschaft (DMykG)
2013-2015 Co-chair, Gordon Conference “Immunology of Fungal Infections”
2013 Member of the programme committee, ASM Candida and Candidiasis Meeting 2014
2013-2020 Organiser & Co-Organizer of FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” (2013, 2016 and 2020) in Jena, Germany
2012-2015 “In house professorship”, Center for Sepsis Control and Care (CSCC), Integriertes Forschungs- und Behandlungszentrum (IFB), Jena
2012 Co-Chair for the ISHAM 2012 conference in Berlin
2011-2018 Member of DFG priority program SPP 1580: “Survival and proliferation of human pathogenic Candida species within phagocytes”
2011-2018 Scientific advisory board Wellcome Trust Strategic Award (WTSA) “Medical Mycology and Fungal Immunology”, Aberdeen, UK
2011-2016 Leading Principal Investigator in the DFG DACH Programme, project: “Microevolution of pathogenic yeasts during interactions with the host immune system”
2011-2015 Co-vice chair, Gordon Conference “Immunology of Fungal Infections”
2011-2014 Member of the Internal Review Board (IRB) of the Center for Sepsis Control and Care (CSCC) in Jena, Germany
2011 Organisation of the international FINSysB research skills training workshop “State-of-the-art infection models”
Since 2010 Steering Committee, International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2010-2012 Co-chair and member of the programme and organisation committee "ISHAM 2012“
2009-2015 Vice President of the International Society for Human and Animal Mycology (ISHAM)
2009-2015 Member of the Scientific Advisory Board for of the next FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle-sur-Loup, France
2008 Fellowship award of the American Academy of Microbiology (AAM)
2008 Heinz-Maurer-Award (co-author)
Since 2007 PI at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
Since 2007 PI at the excellence school Jena School for Microbial Communications (JSMC)
2007-2014 Member and PI of EU ERA-NET PathoGenoMics Network Program CandiCol
2005 Scientific committee “Interdisciplinary Forum on Candida and Candida Infections” in Göttingen
2005 Local scientific committee TIMM 2005 (“Trends in Medical Mycology“) in Berlin
2004-2011 Member and PI of DFG priority program SPP 1160 “Colonisation and infection by human-pathogenic fungi”
2004-2006 Science advisory board of the “FEBS advanced course on Human Fungal Pathogens“
2003-2006 Head of the section "Eukaryotic Pathogens“ of the DGHM
2003 Heinz Seeliger Award, Seeliger Foundation
2003 Becton Dickinson Award of the DGHM
2002-2003 Secretary of the section "Eukaryotic Pathogens“ of the DGHM
2000-2013 Member of Marie Curie Research Training Networks of the European Union (FP5, FP6 and FP7)
Since 2000

Editorial Board / Associate Editor of mBio, Cellular Microbiology, FEMS Yeast Research, F1000, Current Opinion in Microbiology (Section Editor 2009, Editorial Board), VirulenceAd hoc Reviewer for >35 journals incl. Nature, Nature Communication, Nature Microbiology, Nature Reviews Microbiology, Proceeding of the National Academy of Science, PLoS Pathogens, Science Translational Medicine, Current Opinion in Microbiology, Antimicrobial Agents and Chemotherapy, Cellular Microbiology (Highlighted Reviewer for Cellular Microbiology 2016), and others

Reviewer for Grant & Fellowship Applications for Health and Medical Research Fund China (HMRF), Health and Medical Research Fund (HMRF), Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Swiss National Science foundation (SNF), UK-India Education and Research Initiative (UKIERI), i-Move (EU), Agence Nationale de la Rechere France (ANR), Robert Koch Institute (RKI), National Science Centre Poland (NSCP), Biotechnology and Biological Sciences Research Council (BBSRC), Deutsche Forschungsgemeinschaft (DFG), Deutsch-Israelische Stiftung für Wissenschaftliche Forschung und Entwicklung (GIF), European Molecular Biology Organization (EMBO), Medical Research Council (MRC), National Science Foundation (NSF, USA), Netherlands Organisation for Scientific Research (NWO), Research Foundation-Flanders/Fonds Wetenschappelijk Onderzoek (FWO, Belgien), The Royal Society (London, UK), The Welcome Trust UK, Foundation for Polish Science (FNP), European Molecular Biology Conference (EMBC), Studienstiftung des Deutschen Volkes, Bundesministeriums für Bildung und Forschung (BMBF), British Society for Antimicrobial Chemotherapy (BSAC), National Research Foundation (NRF) South Africa, Evaluation of grant proposals and promotions for multiple international universities, Humboldt Stiftung, Deutsche Krebshilfe, Wissenschaftsrat and others
 

Chair, co-chair, organizer and convener of > 50 conferences, meetings and sessions

Since 2000 PI in EU-Projects (Framework Programme 5, 6, 7)
Since 2000 Editorial Board / Associate Editor of mBio, Cellular Microbiology, Microbiology (SGM), BMC Microbiology, FEMS Yeast Research, F1000, Frontiers in Fungi and Their Interactions, Current Medical Mycology, Frontiers in Molecular Innate Immunity, Current Opinion in Microbiology (Section Editor 2009), Virulence
1998 Scientific award (Forschungsförderpreis), DMykG
Since 1995 Reviewer for more than 35 journals
1992-1995 Postdoc fellowships from the EG and DFG

Publications

Alonso-Monge R, Gresnigt MS, Román E, Hube B, Pla J (2021) Candida albicans colonization of the gastrointestinal tract: A double-edged sword. PLOS Pathog 17(7), e1009710.
Austermeier S, Pekmezović M, Porschitz P, Lee S, Kichik N, Moyes DL, Ho J, Kotowicz NK, Naglik JR, Hube B, Gresnigt MS (2021) Albumin neutralizes hydrophobic toxins and modulates Candida albicans pathogenicity. mBio 12(3), e0053121.
Blagojevic M, Camilli G, Maxson M, Hube B, Moyes DL, Richardson JP, Naglik JR (2021) Candidalysin triggers epithelial cellular stresses that induce necrotic death. Cell Microbiol 23(10), e13371.
d'Enfert C, Kaune AK, Alaban LR, Chakraborty S, Cole N, Delavy M, Kosmala D, Marsaux B, Fróis-Martins R, Morelli M, Rosati D, Valentine M, Xie Z, Emritloll Y, Warn PA, Bequet F, Bougnoux ME, Bornes S, Gresnigt MS, Hube B, Jacobsen ID, Legrand M, Leibundgut-Landmann S, Manichanh C, Munro CA, Netea MG, Queiroz K, Roget K, Thomas V, Thoral C, Van den Abbeele P, Walker AW, Brown AJP (2021) The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev 45(3), fuaa060. (Review)
Fischer J, Gresnigt MS, Werz O, Hube B, Garscha U (2021) Candida albicans-induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology. FASEB J 35(10), e21820.
Graf K, Hube B, Brunke S (2021) Experimental evolution of Candida by serial passaging in host cells. Methods Mol Biol 2260, 145-154.
Last A, Maurer M, Mosig AS, Gresnigt MS, Hube B (2021) In vitro infection models to study fungal-host interactions. FEMS Microbiol Rev 45(5), fuab005. (Review)
Liu J, Willems HME, Sansevere EA, Allert S, Barker KS, Lowes DJ, Dixson AC, Xu Z, Miao J, DeJarnette C, Tournu H, Palmer GE, Richardson JP, Barrera FN, Hube B, Naglik JR, Peters BM (2021) A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis. PLoS Pathog 17(9), e1009884.
Mirhakkak M, Schäuble S, Klassert T, Brunke S, Brandt P, Loos D, Uribe R, de Oliveira Lino FS, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss G, Sommer M, Panagiotou G# (2021) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J 15(5), 1257-1270.
Mogavero S, Hube B (2021) Candida albicans Interaction with oral epithelial cells: Adhesion, invasion and damage assays. Methods Mol Biol 2260, 133-143.