Curriculum vitae

Main Research Areas
  • Infection biology of human pathogenic fungi (Candida albicans, C. glabrata)
  • Host-/pathogen-interactions
  • Functional genomics and micro-evolution
  • Infection-associated genes
Professional Career
Since 2007 Head, Dept. Microbial Pathogenicity Mechanisms, HKI Jena
Since 2006 Professor (W3), Chair in Microbial Pathogenicity, FSU Jena
2006-2007 Head of the division FG16 “Mycology”, RKI Berlin
2000-2006 Lecturer in Microbiology, FU Berlin
2000-2006 Head of a research group, RKI Berlin
2000 Habilitation in Molecular Microbiology, University of Hamburg
1996-2000 Assistant Professor (C1), Applied Molecular Biology, University of Hamburg
1995-1996 Research Assistant, Applied Molecular Biology, University of Hamburg
1992-1995 Honour Research Fellow, EG- and DFG-funded, University of Aberdeen, United Kingdom
1991 Dr. rer. nat. in Microbiology, University of Göttingen
1986 Diploma in Biology, University of Göttingen, Germany
Awards · Appointments · Scientific Activities
Since 2020 Member and PI of the DFG priority program SPP 2225 Strategies of Candida albicans and Candida glabrata to exit from macrophages
Since 2020 Member and PI of the ANR/BMBF French-German project on antimicrobial resistance programme “Resistance to antibiotics, focusing on critical resistant bacteria from the WHO priority-1 list of pathogens, and resistance to antifungals“ – “Antifungal Resistance: From Surveillance to Treatment” – AreST
Since 2019 Member and PI of the EU Host-Directed Medicine in invasive FUNgal infections (HDMFun) Horizon 2020; Better Health and care, economic growth and sustainable health systems) RIA
Since 2019 Member and PI of the Wellcome Trust Collaborative Award “Targeting a new kingdom: the nature and significance of Type VI secretion system-mediated anti-fungal activity”
Since 2019 Coordinator RA B Excellence Cluster “Balance of the Microverse” of the FSU
Since 2019 Member and Training Manager of the EU Marie Skłodowska-Curie Innovative Training Network (MC-ITN) “Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections – FunHoMic”
2018-2020 Member of the Review Board (Fachkolleg 204) of the Deutsche Forschungsgemeinschaft, (DFG) 204 (Microbiology, Virology and Immunology)
2018 Member of the International Scientific Committee for the 20th Congress of the International Society for Human and Animal Mycology (ISHAM) 30 June - 4 July 2018 Amsterdam
2017-2020 Speaker and PI of Leibniz Campus “InfectoOptics - Combating infectious diseases with advanced optical methods”
2017 “Drug of the Year” Award of the Leibniz Association
2015-2022 Executive board member of the Centre for Innovation Competence (ZIK) Septomics
2015-2019 Member of the EU MC-ITN “From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts – OPATHY”
2015-2018 Eight publication awards of the DMykG (Co- and Senior author)
2015-2018 Coordinator and PI of Infect-ERA Consortium “FunComPath”: From colonization to infection: dissection of the commensal-to-pathogen shift of Candida albicans
2013-2016 Member of the program committee ASM Candida and candidiasis meeting
2014 Main award (Hauptpreis) of DGHM
Since 2013 Member and Steering Committee of the Leibniz Research Alliance INFECTIONS'21/INFECTIONS
Since 2013 Member, PI and Steering Committee (until 2021) of DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
2013-2017 Member of “International Project Advisory Board” of the Belgian network “MICRODEV – Role of developmental processes in the virulence of human pathogens: from molecular mechanisms to novel therapeutic targets”
Since 2013 Honorary member of Deutschsprachige Mykologische Gesellschaft (DMykG)
2013-2015 Co-chair, Gordon Conference “Immunology of Fungal Infections”
2013-2020 Organiser & Co-Organizer of FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” (2013, 2016 and 2020) in Jena, Germany
2012-2015 “In house professorship”, Center for Sepsis Control and Care (CSCC), Integriertes Forschungs- und Behandlungszentrum (IFB), Jena
2012 Co-Chair for the ISHAM 2012 conference in Berlin
2011-2018 Member of DFG priority program SPP 1580: “Survival and proliferation of human pathogenic Candida species within phagocytes”
2011-2018 Scientific advisory board Wellcome Trust Strategic Award (WTSA) “Medical Mycology and Fungal Immunology”, Aberdeen, UK
2011-2016 Leading Principal Investigator in the DFG DACH Programme, project: “Microevolution of pathogenic yeasts during interactions with the host immune system”
2011-2014 Member of the Internal Review Board (IRB) of the Center for Sepsis Control and Care (CSCC) in Jena, Germany
2011 Organisation of the international FINSysB research skills training workshop “State-of-the-art infection models”
Since 2011 Scientific advisory board Wellcome Trust Strategic Award (WTSA) “Medical Mycology and Fungal Immunology”, University of Aberdeen, UK
Since 2010 Steering Committee, International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2010-2012 Co-chair of the programme and organisation committee "ISHAM 2012“
2009-2015 Vice President of the International Society for Human and Animal Mycology (ISHAM)
2009-2015 Member of the Scientific Advisory Board for of the next FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle-sur-Loup, France
2008 Fellowship award of the American Academy of Microbiology (AAM)
2008 Heinz-Maurer-Award (co-author)
Since 2007 PI at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
Since 2007 PI at the excellence school Jena School for Microbial Communications (JSMC)
2007-2014 Member and PI of EU ERA-NET PathoGenoMics Network Program CandiCol
2005 Scientific committee “Interdisciplinary Forum on Candida and Candida Infections” in Göttingen
2005 Local scientific committee TIMM 2005 (“Trends in Medical Mycology“) in Berlin
2004-2011 Member and PI of DFG priority program SPP 1160 “Colonisation and infection by human-pathogenic fungi”
2004-2006 Science advisory board of the “FEBS advanced course on Human Fungal Pathogens“
2003-2006 Head of the section "Eukaryotic Pathogens“ of the DGHM
2003 Heinz Seeliger Award, Seeliger Foundation
2003 Becton Dickinson Award of the DGHM
2002-2003 Secretary of the section "Eukaryotic Pathogens“ of the DGHM
2000-2013 Member of Marie Curie Research Training Networks of the European Union (FP5, FP6 and FP7)
Since 2000 Editorial Board / Associate Editor of mBio, Cellular Microbiology, FEMS Yeast Research, F1000, Current Opinion in Microbiology (Section Editor 2009, Editorial Board), Virulence Ad hoc Reviewer for >35 journals incl. Nature, Nature Communication, Nature Microbiology, Nature Reviews Microbiology, Proceeding of the National Academy of Science, PLoS Pathogens, Science Translational Medicine, Current Opinion in Microbiology, Antimicrobial Agents and Chemotherapy, Cellular Microbiology (Highlighted Reviewer for Cellular Microbiology 2016), and others Reviewer for Grant & Fellowship Applications for Health and Medical Research Fund China (HMRF), Health and Medical Research Fund (HMRF), Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Swiss National Science foundation (SNF), UK-India Education and Research Initiative (UKIERI), i-Move (EU), Agence Nationale de la Rechere France (ANR), Robert Koch Institute (RKI), National Science Centre Poland (NSCP), Biotechnology and Biological Sciences Research Council (BBSRC), Deutsche Forschungsgemeinschaft (DFG), Deutsch-Israelische Stiftung für Wissenschaftliche Forschung und Entwicklung (GIF), European Molecular Biology Organization (EMBO), Medical Research Council (MRC), National Science Foundation (NSF, USA), Netherlands Organisation for Scientific Research (NWO), Research Foundation-Flanders/Fonds Wetenschappelijk Onderzoek (FWO, Belgien), The Royal Society (London, UK), The Welcome Trust UK, Foundation for Polish Science (FNP), European Molecular Biology Conference (EMBC), Studienstiftung des Deutschen Volkes, Bundesministeriums für Bildung und Forschung (BMBF), British Society for Antimicrobial Chemotherapy (BSAC), National Research Foundation (NRF) South Africa, Evaluation of grant proposals and promotions for multiple international universities, Humboldt Stiftung, Deutsche Krebshilfe, Wissenschaftsrat and others
  Lecturer for Central European Summer Course (CESC), Szeged, Hungary, Woods Hole Course of Molecular Mycology (USA); post-graduation course on Host-Fungus Interactions, Braga, Portugal); summer school “Pathogen-Host Interactions at Cellular Barriers”, Muenster, Germany
  Chair, co-chair, organizer and convener of > 50 conferences, meetings and sessions
Since 2000 PI in EU-Projects (Framework Programme 5, 6, 7)
1998 Scientific award (Forschungsförderpreis), DMykG
1992-1995 Postdoc fellowships from the EG and DFG

Publications

Pekmezovic M, Kaune AK, Austermeier S, Hitzler SUJ, Mogavero S, Hovhannisyan H, Gabaldón T, Gresnigt MS, Hube B (2021) Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells. PLoS Pathog 17(10), e1010037.
Radosa S, Sprague JL, Lau SH, Tóth R, Linde J, Krüger T, Sprenger M, Kasper L, Westermann M, Kniemeyer O, Hube B, Brakhage AA, Gácser A, Hillmann F (2021) The fungivorous amoeba Protostelium aurantium targets redox homeostasis and cell wall integrity during intracellular killing of Candida parapsilosis. Cell Microbiol 23(11), e13389.
Schaefer S, Pham TTP, Brunke S, Hube B, Jung K, Lenardon MD, Boyer C (2021) Rational design of an antifungal polyacrylamide library with reduced host-cell toxicity. ACS Appl Mater Interfaces 13(23), 27430-27444.
Siscar-Lewin S, Gabaldón T, Aldejohann AM, Kurzai O, Hube B, Brunke S (2021) Transient mitochondria dysfunction confers fungal cross-resistance against phagocytic killing and fluconazole. mBio 12(3), e0112821.
Sprenger M, Brunke S, Hube B, Kasper L (2021) A TRP1-marker-based system for gene complementation, overexpression, reporter gene expression, and gene modification in Candida glabrata. FEMS Yeast Res 20(8), foaa066.
Vij R, Hube B, Brunke S (2021) Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria. Comput Struct Biotechnol J 19, 1244-1252. (Review)
Wich M, Greim S, Ferreira-Gomes M, Krüger T, Kniemeyer O, Brakhage AA, Jacobsen ID, Hube B, Jungnickel B (2021) Functionality of the human antibody response to Candida albicans. Virulence 12(1), 3137-3148.
Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DB (2021) Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization. Immunity 54(11), 2595-2610.e7..
Zhang S, Edwards TN, Mogavero S, Mathers AR, Hube B, Berman J, Bougnoux ME, D'Enfert C, Kaplan DH (2021) Adenosine triphosphate released by Candida albicans is associated with reduced skin infectivity. J Invest Dermatol 141(9), 2306-2310.
Commichau FM, Anstatt J, Krappmann S, Stegmann E, Banhart S, Papenfort K, Brunke S, Hube B, Bramkamp M, Herbert M, Sander J, Mueller JW, Wagner M, Daus ML (2020) Wettrüsten zwischen Pilz und Wirt. BIOSpektrum 26(3), 280-286. (Review)