Curriculum vitae

Main Research Areas
  • Infection biology of human pathogenic fungi (Candida albicans, C. glabrata)
  • Host-/pathogen-interactions
  • Functional genomics and micro-evolution
  • Infection-associated genes
Professional Career
Since 2007 Head, Dept. Microbial Pathogenicity Mechanisms, HKI Jena
Since 2006 Professor (W3), Chair in Microbial Pathogenicity, FSU Jena
2006-2007 Head of the division FG16 “Mycology”, RKI Berlin
2000-2006 Lecturer in Microbiology, FU Berlin
2000-2006 Head of a research group, RKI Berlin
2000 Habilitation in Molecular Microbiology, University of Hamburg
1996-2000 Assistant Professor (C1), Applied Molecular Biology, University of Hamburg
1995-1996 Research Assistant, Applied Molecular Biology, University of Hamburg
1992-1995 Honour Research Fellow, EG- and DFG-funded, University of Aberdeen, United Kingdom
1991 Dr. rer. nat. in Microbiology, University of Göttingen
1986 Diploma in Biology, University of Göttingen, Germany
Awards · Appointments · Scientific Activities

Since 2019

Coordinator RA B Excellence Cluster “Balance of the Microverse” of the FSU
Since 2019 Member and Training Manager of the EU Marie Skłodowska-Curie Innovative Training Network (MC-ITN) “Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections – FunHoMic”
2018-2020 Member of the Review Board (Fachkolleg 204) of the Deutsche Forschungsgemeinschaft, (DFG) 204 (Microbiology, Virology and Immunology)
2018 Member of the International Scientific Committee for the 20th Congress of the International Society for Human and Animal Mycology (ISHAM) 30 June - 4 July 2018 Amsterdam
2017-2019 Speaker and PI of Leibniz Campus “InfectoOptics - Combating infectious diseases with advanced optical methods”
2017 “Drug of the Year” Award of the Leibniz Association
Since 2015 Executive board member of the Centre for Innovation Competence (ZIK) Septomics
2015-2019 Member of the EU MC-ITN “From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts – OPATHY”
2015-2018 Eight publication awards of the DMykG (Co- and Senior author)
2015-2018 Coordinator and PI of Infect-ERA Consortium “FunComPath”: From colonization to infection: dissection of the commensal-to-pathogen shift of Candida albicans
2014-2016 Member of the program committee ASM Candida and candidiasis meeting
2014 Main award (Hauptpreis) of DGHM
Since 2013 Member and Steering Committee of the Leibniz Research Alliance INFECTIONS'21/INFECTIONS
Since 2013 Member, PI and Steering Committee of DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2013 Organiser & Co-Organizer of FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” (2013, 2016 and 2020) in Jena, Germany
2013-2017 Member of “International Project Advisory Board” of the Belgian network “MICRODEV – Role of developmental processes in the virulence of human pathogens: from molecular mechanisms to novel therapeutic targets”
Since 2013 Honorary member of Deutschsprachige Mykologische Gesellschaft (DMykG)
2013-2015 Co-chair, Gordon Conference “Immunology of Fungal Infections”
2013 Member of the programme committee, ASM Candida and Candidiasis Meeting 2014
2013-2020 Organiser & Co-Organizer of FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” (2013, 2016 and 2020) in Jena, Germany
2012-2015 “In house professorship”, Center for Sepsis Control and Care (CSCC), Integriertes Forschungs- und Behandlungszentrum (IFB), Jena
2012 Co-Chair for the ISHAM 2012 conference in Berlin
2011-2018 Member of DFG priority program SPP 1580: “Survival and proliferation of human pathogenic Candida species within phagocytes”
2011-2018 Scientific advisory board Wellcome Trust Strategic Award (WTSA) “Medical Mycology and Fungal Immunology”, Aberdeen, UK
2011-2016 Leading Principal Investigator in the DFG DACH Programme, project: “Microevolution of pathogenic yeasts during interactions with the host immune system”
2011-2015 Co-vice chair, Gordon Conference “Immunology of Fungal Infections”
2011-2014 Member of the Internal Review Board (IRB) of the Center for Sepsis Control and Care (CSCC) in Jena, Germany
2011 Organisation of the international FINSysB research skills training workshop “State-of-the-art infection models”
Since 2010 Steering Committee, International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2010-2012 Co-chair and member of the programme and organisation committee "ISHAM 2012“
2009-2015 Vice President of the International Society for Human and Animal Mycology (ISHAM)
2009-2015 Member of the Scientific Advisory Board for of the next FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle-sur-Loup, France
2008 Fellowship award of the American Academy of Microbiology (AAM)
2008 Heinz-Maurer-Award (co-author)
Since 2007 PI at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
Since 2007 PI at the excellence school Jena School for Microbial Communications (JSMC)
2007-2014 Member and PI of EU ERA-NET PathoGenoMics Network Program CandiCol
2005 Scientific committee “Interdisciplinary Forum on Candida and Candida Infections” in Göttingen
2005 Local scientific committee TIMM 2005 (“Trends in Medical Mycology“) in Berlin
2004-2011 Member and PI of DFG priority program SPP 1160 “Colonisation and infection by human-pathogenic fungi”
2004-2006 Science advisory board of the “FEBS advanced course on Human Fungal Pathogens“
2003-2006 Head of the section "Eukaryotic Pathogens“ of the DGHM
2003 Heinz Seeliger Award, Seeliger Foundation
2003 Becton Dickinson Award of the DGHM
2002-2003 Secretary of the section "Eukaryotic Pathogens“ of the DGHM
2000-2013 Member of Marie Curie Research Training Networks of the European Union (FP5, FP6 and FP7)
Since 2000

Editorial Board / Associate Editor of mBio, Cellular Microbiology, FEMS Yeast Research, F1000, Current Opinion in Microbiology (Section Editor 2009, Editorial Board), VirulenceAd hoc Reviewer for >35 journals incl. Nature, Nature Communication, Nature Microbiology, Nature Reviews Microbiology, Proceeding of the National Academy of Science, PLoS Pathogens, Science Translational Medicine, Current Opinion in Microbiology, Antimicrobial Agents and Chemotherapy, Cellular Microbiology (Highlighted Reviewer for Cellular Microbiology 2016), and others

Reviewer for Grant & Fellowship Applications for Health and Medical Research Fund China (HMRF), Health and Medical Research Fund (HMRF), Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Swiss National Science foundation (SNF), UK-India Education and Research Initiative (UKIERI), i-Move (EU), Agence Nationale de la Rechere France (ANR), Robert Koch Institute (RKI), National Science Centre Poland (NSCP), Biotechnology and Biological Sciences Research Council (BBSRC), Deutsche Forschungsgemeinschaft (DFG), Deutsch-Israelische Stiftung für Wissenschaftliche Forschung und Entwicklung (GIF), European Molecular Biology Organization (EMBO), Medical Research Council (MRC), National Science Foundation (NSF, USA), Netherlands Organisation for Scientific Research (NWO), Research Foundation-Flanders/Fonds Wetenschappelijk Onderzoek (FWO, Belgien), The Royal Society (London, UK), The Welcome Trust UK, Foundation for Polish Science (FNP), European Molecular Biology Conference (EMBC), Studienstiftung des Deutschen Volkes, Bundesministeriums für Bildung und Forschung (BMBF), British Society for Antimicrobial Chemotherapy (BSAC), National Research Foundation (NRF) South Africa, Evaluation of grant proposals and promotions for multiple international universities, Humboldt Stiftung, Deutsche Krebshilfe, Wissenschaftsrat and others
 

Chair, co-chair, organizer and convener of > 50 conferences, meetings and sessions

Since 2000 PI in EU-Projects (Framework Programme 5, 6, 7)
Since 2000 Editorial Board / Associate Editor of mBio, Cellular Microbiology, Microbiology (SGM), BMC Microbiology, FEMS Yeast Research, F1000, Frontiers in Fungi and Their Interactions, Current Medical Mycology, Frontiers in Molecular Innate Immunity, Current Opinion in Microbiology (Section Editor 2009), Virulence
1998 Scientific award (Forschungsförderpreis), DMykG
Since 1995 Reviewer for more than 35 journals
1992-1995 Postdoc fellowships from the EG and DFG

Publications

Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E (2016) In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence 7(7), 819-825.
Gerwien F, Safyan A, Wisgott S, Hille F, Kämmer P, Linde J, Brunke S, Kasper L, Hube B (2016) A novel hybrid iron regulation network combines features from pathogenic and non-pathogenic yeasts. mBio 7(5), e01782-16.
Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055.
Höfs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54(3), 149-169. (Review)
Jakab Á, Mogavero S, Förster TM, Pekmezovic M, Jablonowski N, Dombrádi V, Pócsi I, Hube B (2016) Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells. Microbiology 162(12), 2116-2125.
Khandelwal NK, Kämmer P, Förster TM, Singh A, Coste AT, Andes DR, Hube B, Sanglard D, Chauhan N, Kaur R, d'Enfert C, Mondal AK, Prasad R (2016) Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence. Biochem J 473(11), 1537-1552.
Krappmann S, Meyer V, Hube B, Kämper J (2016) Interdisziplinäres Forum zu Virulenzmechanismen phyto- und humanpathogener Pilze. In: Springer Spektrum (ed.) BIOspektrum IFO-Fun 2016: Interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi, Erlangen, 10/05/2016-10/07/2016, 7-2016, pp. 742.Springer-Verlag GmbH, Heidelberg. (Review)
Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406.
Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68.
Naranjo-Ortíz MA, Brock M, Brunke S, Hube B, Marcet-Houben M, Gabaldón T (2016) Widespread inter- and intra-Ddmain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Front Microbiol 7, 2001.