(2022)
Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites.
mSystems 7(1),
e0121421.
Dirk Hoffmeister
Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.deCurriculum vitae
Main Research Areas
- Biochemical and genetic basis of fungal natural product biosyntheses
- Natural products of basidiomycetes and Ralstonia solanacearum
- Microbial nonribosomal peptide synthetases
Professional Career
| 2014- | Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena |
| 2009-2014 | Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena |
| 2007-2009 | Assistant professor (tenure track) University of Minnesota, Saint Paul, MN, USA |
| 2008 | Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg |
| 2004-2007 | Research assistant, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg |
| 2002-2004 | Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship) |
| 2002 | Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg |
| 1998 | Diploma in biology at the Eberhard-Karls-University, Tübingen |
Awards · Appointments · Scientific Activities
| Since 2016 | Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena |
| 2013-2016 | Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM). |
| Since 2011 | Member of the editorial board of various journals |
Publications
(2022)
Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines.
Chembiochem ,
(2022)
Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor.
Angew Chem Int Ed
[Accepted]
(2021)
Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity.
J Nat Prod 84(4),
1403-1408.
(2021)
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.
Nat Prod Rep 38(4),
702-722.
(Review)
(2021)
Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis.
Environ Microbiol 23(8),
4360-4371.
(2021)
Structure elucidation and spectroscopic analysis of chromophores produced by oxidative psilocin dimerization.
Chemistry 27(47),
12166-12171.
(2021)
Taking different roads: L-Tryptophan as the origin of psilocybe natural products.
ChemPlusChem 86(1),
28-35.
(2021)
Frankobactin metallophores produced by nitrogen-fixing Frankia actinobacteria function in toxic metal sequestration.
J Nat Prod 84(4),
1216-1225.
(2020)
Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms.
Chem Eur J 26(3),
729-734.
