Dirk Hoffmeister

Head · Pharmaceutical Microbiology +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.de

Curriculum vitae

Main Research Areas

Biochemical and genetic basis of fungal natural product biosyntheses
Natural products of basidiomycetes and Ralstonia solanacearum
Microbial nonribosomal peptide synthetases

Professional Career

2014-	Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena
2009-2014	Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena
2007-2009	Assistant professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008	Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg
2004-2007	Research assistant, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg
2002-2004	Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)
2002	Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg
1998	Diploma in biology at the Eberhard-Karls-University, Tübingen

Awards · Appointments · Scientific Activities

Since 2016	Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena
2013-2016	Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).
Since 2011	Member of the editorial board of various journals

Publications

Fricke J, Sherwood AM, Halberstadt AL, Kargbo RB, Hoffmeister D (2021) Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity. J Nat Prod 84(4), 1403-1408.

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Gressler M, Löhr NA, Schäfer T, Lawrinowitz S, Seibold PS, Hoffmeister D (2021) Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota. Nat Prod Rep 38(4), 702-722. (Review)

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Herkersdorf S, Krüger T, Wein P, Löffler S, Fontaine T, Gressler M, Hertweck C, Brakhage AA, Hoffmeister D (2021) Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis. Environ Microbiol 23(8), 4360-4371.

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Lenz C, Dörner S, Sherwood A, Hoffmeister D (2021) Structure elucidation and spectroscopic analysis of chromophores produced by oxidative psilocin dimerization. Chemistry 27(47), 12166-12171.

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Lenz C, Sherwood A, Kargbo R, Hoffmeister D (2021) Taking different roads: L-Tryptophan as the origin of psilocybe natural products. ChemPlusChem 86(1), 28-35.

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Mohr JF, Baldeweg F, Deicke M, Morales-Reyes CF, Hoffmeister D, Wichard T (2021) Frankobactin metallophores produced by nitrogen-fixing Frankia actinobacteria function in toxic metal sequestration. J Nat Prod 84(4), 1216-1225.

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Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.

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Demmler R, Fricke J, Dörner S, Gressler M, Hoffmeister D (2020) S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms. ChemBioChem 21(9), 1364-1371.

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Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285.

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Lenz C, Wick J, Braga D, Garcia-Altares M, Lackner G, Hertweck C, Gressler M, Hoffmeister D (2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454.

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