(2024)
Selective uptake into inflamed human intestinal tissue and immune cell targeting by wormlike polymer micelles.
Small 20(21),
2470162.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
| since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
| since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
| since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
| since 2023 | Editor: PLOS Complex Systems |
| since 2023 | Editor: Biological Imaging |
| since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
| since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
| since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
| since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2024)
Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages.
Immunology 173(4),
748-767.
(2024)
The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism.
mBio 15(3),
e0019524.
(2024)
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.
Biomaterials 307,
122525.
(2024)
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model.
Front Immunol 15,
1432307.
(2024)
NFDI4BIOIMAGE - National research data infrastructure for microscopy and bioimage analysis.
Zenodo ,
10.3389/fimmu.2024.1432307.
(Review)
(2024)
Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology.
Front Hematol 3,
(2024)
The global RNA–RNA interactome of Klebsiella pneumoniae unveils a small RNA regulator of cell division.
Proc Natl Acad Sci U S A 121(9),
e2317322121.
(2024)
Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung.
Commun Biol 7(1),
1615.
(2024)
Deep learning-based characterization of neutrophil activation phenotypes in ex vivo human Candida blood infections.
Comput Struct Biotechnol J 23,
1260-1273.
