(2018)
Untangling cell tracks: Quantifying cell migration by time lapse image data analysis.
Cytometry A 93(3),
357-370.
(Review)
Curriculum vitae
Main Research Areas
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Scientific Activities and Functions
| since 2021 | Deputy Coordinator of the Jena School for Microbial Communication |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” | |
| since 2019 | Speaker of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2014 | Editor: Computational and Mathematical Models in Medicine |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Member: International Leibniz Research School for Microbial and Biomolecular Interactions |
| since 2011 | Member: Jena School for Microbial Communication |
Publications
(2018)
Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients.
Front Immunol 9,
667.
(2017)
Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays.
Medical Image Analysis 36,
172-183.
(2017)
Mast cells acquire MHCII from dendritic cells during skin inflammation.
J Exp Med 214(12),
3791-3811.
(2017)
Systems Biology of Infection.
In: NOVA ACTA LEOPOLDINA (ed.) Crossing Boundaries in Science.
Documentation of the Workshop of the German National Academy of Sciences Leopoldina, Weimar, 06/30/2016-07/02/2016, 419, pp. 45-51.Wissenschaftliche Verlagsgesellschaft Stuttgart, Halle (Saale).
ISBN: 978-3-8047-3758. (Review)
(2017)
Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging.
Sci Rep 7,
2217.
(2017)
Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.
J Am Soc Nephrol 28(2),
452-459.
(2017)
Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling.
Front Immunol 8,
1692.
(2017)
Segmentation of clusters by template rotation expectation maximization.
Comput Vis Image Underst 152,
64-72.
(2017)
Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.
Sci Rep 7,
44434.
