(2017)
Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging.
Sci Rep 7,
2217.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Scientific Activities and Functions
| since 2021 | Deputy Coordinator of the Jena School for Microbial Communication |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” | |
| since 2019 | Speaker of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2014 | Editor: Computational and Mathematical Models in Medicine |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Member: International Leibniz Research School for Microbial and Biomolecular Interactions |
| since 2011 | Member: Jena School for Microbial Communication |
Publications
(2017)
Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.
J Am Soc Nephrol 28(2),
452-459.
(2017)
Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling.
Front Immunol 8,
1692.
(2017)
Segmentation of clusters by template rotation expectation maximization.
Comput Vis Image Underst 152,
64-72.
(2017)
Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.
Sci Rep 7,
44434.
(2016)
FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.
J Immunol 197(2),
620-629.
(2016)
Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs.
Sci Rep 6,
27807.
(2015)
Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils.
Medical Image Analysis 20(1),
34-51.
(2015)
Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes.
Cell Microbiol 17(9),
1259-1276.
(2015)
Image-based Systems Biology: what you get is more than you can see.
G.I.T. Laboratory Journal Europe 19,
13-15.
