Marc Thilo Figge

Prof. Dr. Marc Thilo Figge

Applied Systems Biology +49 3641 532-1416 thilo.figge@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Host-pathogen interaction on human pathogenic fungi
  • Automated processing of microscopic images
  • Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena
since 2011 Head of Research Group Applied Systems Biology, Leibniz-HKI
2011-2021 Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena
2005-2010 Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt
2001-2005 Research assistant in Computer Physics at the University Groningen (NL)
2000 Dr. rer. nat. in Physics at the University Groningen (NL)
1995 Diploma in Physics at the University Dortmund
Awards · Appointments · Scientific Activities

Awards

2011 - 2017 Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS)

Scientific Activities and Functions

since 2021 Deputy Coordinator of the Jena School for Microbial Communication
since 2019 Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse”
Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse”
since 2019 Speaker of Leibniz ScienceCampus “InfectoOptics”
since 2019 Editor: Scientific Reports
since 2017 Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology
since 2017 PI and member of the DFG-Collaborative Research Center 1278 PolyTarget
since 2017 Editor: Cytometry A
since 2015 Member: Jena Center for Soft Matter
since 2015 Member: Michael Stifel Center for Data-Driven and Simulation Science
since 2014 PI and member of the DFG-Collaborative Research Center 124 FungiNet
since 2014 Editor: Computational and Mathematical Models in Medicine
since 2012 Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB)
since 2011 Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI)
since 2011 Member: International Leibniz Research School for Microbial and Biomolecular Interactions
since 2011 Member: Jena School for Microbial Communication

Publications

Mattern DJ, Schoeler H, Weber J, Novohradská S, Kraibooj K, Dahse HM, Hillmann F, Valiante V, Figge MT, Brakhage AA (2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161.
Medyukhina A, Timme S, Mokhtari Z, Figge MT (2015) Image-based Systems Biology of Infection. Cytometry A 87(6), 462-470.
Mokhtari Z*, Mech F*, Zehentmeier S, Hauser AE, Figge MT (2015) Quantitative image analysis of cell colocalization in murine bone marrow. Cytometry A 87(6), 503-512, *authors contributed equally.
Pollmächer J, Figge MT (2015) Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli. Frontiers in Microbiology 6(503),
Svensson C-M, Hübler R, Figge MT (2015) Automated classification of circulating tumor cells and the impact of inter-observer variability on classifier training and performance. Journal of Immunology Research 2015(Article ID 573165), 9.
Hünniger K*, Lehnert T*, Bieber K, Martin R, Figge MT⁺, Kurzai O⁺ (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally.
Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T (2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155.
Kraibooj K*, Park HR*, Dahse HM, Skerka C, Voigt K⁺, Figge MT⁺ (2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally.
Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139.
Pollmächer J, Figge MT (2014) Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection. PLOS ONE 9(10), e111630.