(2017)
Mast cells acquire MHCII from dendritic cells during skin inflammation.
J Exp Med 214(12),
3791-3811.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
since 2023 | Editor: PLOS Complex Systems |
since 2023 | Editor: Biological Imaging |
since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
since 2019 | Editor: Scientific Reports |
since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
since 2017 | Editor: Cytometry A |
since 2015 | Member: Jena Center for Soft Matter |
since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2017)
Systems Biology of Infection.
In: NOVA ACTA LEOPOLDINA (ed.) Crossing Boundaries in Science.
Documentation of the Workshop of the German National Academy of Sciences Leopoldina, Weimar, 06/30/2016-07/02/2016, 419, pp. 45-51.Wissenschaftliche Verlagsgesellschaft Stuttgart, Halle (Saale).
ISBN: 978-3-8047-3758. (Review)
(2017)
Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.
J Am Soc Nephrol 28(2),
452-459.
(2017)
Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling.
Front Immunol 8,
1692.
(2017)
Segmentation of clusters by template rotation expectation maximization.
Comput Vis Image Underst 152,
64-72.
(2017)
Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.
Sci Rep 7,
44434.
(2016)
FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.
J Immunol 197(2),
620-629.
(2016)
Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs.
Sci Rep 6,
27807.
(2015)
Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils.
Medical Image Analysis 20(1),
34-51.
(2015)
Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes.
Cell Microbiol 17(9),
1259-1276.