(2022)
Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition.
Microbiol Spectr 10(5),
e0133122.
Prof. Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head +49 3641 532-1525 christine.beemelmanns@leibniz-hki.deCurriculum vitae
Main Research Areas
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Characterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
| since 01/2022 | Professor of Biochemistry of Microbial Metabolism at the University of Leipzig |
| Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
| 2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
| 2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
| 2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
| 2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
| 2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
| 2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
| 2021 | Nachwuchswissenschaftler-Preise für Naturstoffforschung |
| 2020 | Dozentenpreis des Fonds der Chemischen Industrie |
| 2020 | Visiting Professor in Madison Wisconsin USA |
| 2019-2024 | ERC Starting GRant MORPHEUS |
| 2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
| Since 2014 | Membership VAAM, FEMS and IUMS |
| Since 2014 | Membership Dechema |
| Since 2014 | Membership National Research Foundation of Korea |
| 2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
| 2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
| 2010-2011 | Postdoc fellowship from the DAAD |
| Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
| 2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
| 2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
| 2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
| 2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
| 2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
| 2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
| Since 2003 | Member of the GDCH |
| 2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
| 2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
Publications
(2022)
Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites.
mSystems 7(1),
e0121421.
(2022)
GNPS**-guided discovery of madurastatins A1, A2, E1, F, and G1, siderophores from the termite-associated Actinomadura sp. RB99. (GNPS=global natural product social molecular networking platform.)
Chemistry 28(36),
e202200612.
(2022)
Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity.
Beilstein J Org Chem 18,
722-731.
(2022)
Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta.
Angew Chem Int Ed 61(41),
e202209105.
(2022)
Application of pyrrolo-protected amino aldehydes in the stereoselective synthesis of anti 1,2-amino alcohols.
ChemCom 58(64),
8990-8993.
(2021)
Recent highlights of biosynthetic studies on marine natural products.
Org Biomol Chem 19(1),
123-140.
(Review)
(2021)
Genome reduction and relaxed selection is associated with the transition to symbiosis in the basidiomycete genus Podaxis.
iScience 24(6),
102680.
(2021)
Two distinct bacterial biofilm components trigger metamorphosis in the colonial hydrozoan Hydractinia echinata.
mBio 12(3),
e0040121.
(2021)
Revised structural assignment of azalomycins based on genomic and chemical analysis.
Org Chem Front 8,
4791-4798.
