Systems biology of sepsis

One of our main aims is the establishment of a pipeline enabling the analysis of gene expressions and of (epi-) genome data from blood samples, clinical data and metabolite concentrations for the improvement of the diagnosis and treatment of sepsis. Thereby, our focus is on understanding the diverse clinical interactions on a molecular level taking network-based models into account. Gene expression profiles and metabolite concentrations are matched with signal transfer and regulatory as well as metabolic networks.

Subsequently, statistical analyses are carried out. The working group is part of the Center for Sepsis Control and Care (CSCC) and is funded by the Federal Ministry for Education and Research (BMBF).