Prof. Dr. Sebastian Weis

Translational Infection Medicine · Head +49 3641 532-1771 Sebastian.Weis@med.uni-jena.de

Curriculum vitae

Main Research Areas

Disease Tolerance to Infection
Innate Immunity
Heme Metabolism
Metabolic Adaptation
Sepsis
Staphylococcus aureus Bacteremia

Professional Career

since 2021	W3 Professor for "Translational Infection Research", FSU Jena
since 2021	Member of the Ethics Committee, FSU Jena
2021	Call W2 Professorship "Inflammation and Haematopoiesis", TU Dresden, declined
2019	Senior Physician, Institute for Infectious Medicine and Hospital Hygiene
2019	Call W3 Professorship "Clinical Infectious Disease", Tübingen, declined
2019	Call W2 professorship "Clinical Infectiology and Immunology", UKE Hamburg, declined
seit 2019	Subgroup Coordinator, Cluster of Excellence "Balance of the Microverse", FSU Jena
2018	Subspecialisation in Clinical Infectious Disease
2018	Member of the Board IFB Center for Sepsis Control and Care, FSU Jena
2018	Member Cluster of Excellence "Balance of the Microverse”, FSU Jena
2018	Examiner 3^rd State Examination in Human Medicine
2017	Habilitation and Venia legendi Internal Medicine, FSU Jena
2015	Training in Clinical Infectiology with Prof. M.W. Pletz, JUH
2012-2015	Postdoctoral Fellow, Instituto Gulbenkian de Ciência (IGC), Portugal
2012	Specialist Examination in Internal Medicine
2007-2012	Specialist Training in Internal Medicine with Prof. J.Mössner, Leipzig University Hospital and Prof. G.Hindricks, Heart Center Leipzig
2008	Medical Dissertation “On Paraenzymatic Functions of Heme Oxygenease-1” (summa cum laude), University of Leipzig, Germany
2007	Visiting Researcher, MRC Fajara, The Gambia, West-Afrika
2006	Approbation/Physician's license
2005	Clinical Elective, Medical Research Council, Fajara, The Gambia
2002-2003	Visiting Researcher, Dept. of Pediatrics, Stanford University, USA
1999-2006	Studies of Medicine, University of Leipzig, Germany; Practical Year: Children´s Hospital of Philadelphia, USA and St. Georg Hospital, Leipzig, Germany

Awards · Appointments · Scientific Activities

2018	Winner Science Slam, KIT 2018
2018	Best Oral Presentation Award, 10th Meeting of HO, Seoul
2017	Hugo-Schottmüller Award of the German Sepsis Society
2017	Best Abstract Award, International Sepsis Forum
2012-2014	DFG Fellowship for Research Abroad
2010	Formula 1 Research Fellowship, University of Leipzig
2008	Doberentz Prize of the University of Leipzig for Outstanding Dissertations

Publications

Bahrs C, Schönherr C, Panning M, Rose N, Dähne T, Hagel S, Weis S, Rupp J, Rohde G, Witzenrath M, Pletz MW (2024) Frequency and clinical significance of Herpes simplex virus type 1/2 reactivation in adult patients with mild to moderately severe community-acquired pneumonia: a multicentre cohort study. Infection , 1-7.

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Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, Bock C, Calandra T, Gat-Viks I, Kyriazopoulou E, Lupse M, Monneret G, Pickkers P, Schultze JL, van der Poll T, van de Veerdonk FL, Vlaar APJ, Weis S, Wiersinga WJ, Netea MG (2024) The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat Immunol 25(1), 19-28. (Review)

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Kaasch AJ, López-Cortés LE, Rodríguez-Baño J, Cisneros JM, Dolores Navarro M, Fätkenheuer G, Jung N, Rieg S, Lepeule R, Coutte L, Bernard L, Lemaignen A, Kösters K, MacKenzie CR, Soriano A, Hagel S, Fantin B, Lafaurie M, Talarmin JP, Dinh A, Guimard T, Boutoille D, Welte T, Reuter S, Kluytmans J, Martin ML, Forestier E, Stocker H, Vitrat V, Tattevin P, Rommerskirchen A, Noret M, Adams A, Kern WV, Hellmich M, Seifert H (2024) Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial. Lancet Infect Dis 24(5), 523-534.

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Schnizer M, Schellong P, Rose N, Fleischmann-Struzek C, Hagel S, Abbas M, Payne B, Evans RN, Pletz MW, Weis S (2024) Long versus short course anti-microbial therapy of uncomplicated Staphylococcus aureus bacteraemia: a systematic review. Clin Microbiol Infect 30(10), 1254-1260.

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Slim MA, van Mourik N, Bakkerus L, Fuller K, Acharya L, Giannidis T, Dionne JC, Oczkowski SJW, Netea MG, Pickkers P, Giamarellos-Bourboulis EJ, Müller MCA, van der Poll T, Wiersinga WJ, Vlaar APJ, van Vught LA (2024) Towards personalized medicine: a scoping review of immunotherapy in sepsis. Crit Care 28(1), 183. (Review)

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Susan Westfall, Maria E. Gentile, Tayla M. Olsen, Danielle Karo-Atar, Andrei Bogza, Franziska Röstel, Ryan D. Pardy, Giordano Mandato, Ghislaine Fontes, View ORCID ProfileDe’Broski Herbert, Heather J. Melichar, Valerie Abadie, Martin J. Richer, Donald C. Vinh, Joshua F. E. Koenig, View ORCID ProfileOliver J. Harrison, View ORCID ProfileMaziar Divangahi, Sebastian Weis, Alex Gregorieff, View ORCID ProfileIrah L. King (2024) A type 1 immune-stromal cell network mediates disease tolerance and barrier protection against intestinal infection. bioRxiv [Preprint]

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Thomas-Rüddel D, Bauer M, Moita LF, Helbig C, Schlattmann P, Ehler J, Rahmel T, Meybohm P, Gründling M, Schenk H, Köcher T, Brunkhorst FM, Gräler M, Heger AJ, Weis S (2024) Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial. BMJ Open 14(4), e075158.

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von Loeffelholz C, Winkler R, Weigel C, Piskor EM, Vivas W, Rauchfuß F, Settmacher U, Rubio I, Weis S, Gräler MH, Bauer M, Kosan C (2024) Increased peritoneal B1-like cells during acute phase of human septic peritonitis. iScience 27(7), 110133.

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Weis S, King IL, Vivas W (2024) To sense or not to sense, Paneth cell regulation of mucosal immunity. Cell Host Microbe 32(10), 1648-1650.

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Wu Q, Carlos AR, Braza F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP (2024) Ferritin heavy chain supports stability and function of the regulatory T cell lineage. EMBO J 43(8), 1445-1483.

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