Prof. Dr. Sebastian Weis

Translational Infection Medicine · Head +49 3641 532-1771 Sebastian.Weis@med.uni-jena.de

Curriculum vitae

Main Research Areas

Disease Tolerance to Infection
Innate Immunity
Heme Metabolism
Metabolic Adaptation
Sepsis
Staphylococcus aureus Bacteremia

Professional Career

since 2021	W3 Professor for "Translational Infection Research", FSU Jena
since 2021	Member of the Ethics Committee, FSU Jena
2021	Call W2 Professorship "Inflammation and Haematopoiesis", TU Dresden, declined
2019	Senior Physician, Institute for Infectious Medicine and Hospital Hygiene
2019	Call W3 Professorship "Clinical Infectious Disease", Tübingen, declined
2019	Call W2 professorship "Clinical Infectiology and Immunology", UKE Hamburg, declined
seit 2019	Subgroup Coordinator, Cluster of Excellence "Balance of the Microverse", FSU Jena
2018	Subspecialisation in Clinical Infectious Disease
2018	Member of the Board IFB Center for Sepsis Control and Care, FSU Jena
2018	Member Cluster of Excellence "Balance of the Microverse”, FSU Jena
2018	Examiner 3^rd State Examination in Human Medicine
2017	Habilitation and Venia legendi Internal Medicine, FSU Jena
2015	Training in Clinical Infectiology with Prof. M.W. Pletz, JUH
2012-2015	Postdoctoral Fellow, Instituto Gulbenkian de Ciência (IGC), Portugal
2012	Specialist Examination in Internal Medicine
2007-2012	Specialist Training in Internal Medicine with Prof. J.Mössner, Leipzig University Hospital and Prof. G.Hindricks, Heart Center Leipzig
2008	Medical Dissertation “On Paraenzymatic Functions of Heme Oxygenease-1” (summa cum laude), University of Leipzig, Germany
2007	Visiting Researcher, MRC Fajara, The Gambia, West-Afrika
2006	Approbation/Physician's license
2005	Clinical Elective, Medical Research Council, Fajara, The Gambia
2002-2003	Visiting Researcher, Dept. of Pediatrics, Stanford University, USA
1999-2006	Studies of Medicine, University of Leipzig, Germany; Practical Year: Children´s Hospital of Philadelphia, USA and St. Georg Hospital, Leipzig, Germany

Awards · Appointments · Scientific Activities

2018	Winner Science Slam, KIT 2018
2018	Best Oral Presentation Award, 10th Meeting of HO, Seoul
2017	Hugo-Schottmüller Award of the German Sepsis Society
2017	Best Abstract Award, International Sepsis Forum
2012-2014	DFG Fellowship for Research Abroad
2010	Formula 1 Research Fellowship, University of Leipzig
2008	Doberentz Prize of the University of Leipzig for Outstanding Dissertations

Publications

Mourits VP, van Puffelen JH, Novakovic B, Bruno M, Ferreira AV, Arts RJ, Groh L, Crișan TO, Zwaag J, Jentho E, Kox M, Pickkers P, van de Veerdonk FL, Weis S, Oosterwijk E, Vermeulen SH, Netea MG, Joosten LA (2021) Lysine methyltransferase G9a is an important modulator of trained immunity. Clin Transl Immunology 10(2), e1253.

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Osuchowski MF, Winkler MS, Skirecki T, Cajander S, Shankar-Hari M, Lachmann G, Monneret G, Venet F, Bauer M, Brunkhorst FM, Weis S, Garcia-Salido A, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Almansa R, de la Fuente A, Martin-Loeches I, Meisel C, Spinetti T, Schefold JC, Cilloniz C, Torres A, Giamarellos-Bourboulis EJ, Ferrer R, Girardis M, Cossarizza A, Netea MG, van der Poll T, Bermejo-Martín JF, Rubio I (2021) The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 9(6), 622-642. (Review)

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Scholz J, Wetzker W, Licht A, Heintzmann R, Scherag A, Weis S, Pletz M, Betsch C, Bauer M, Dickmann P (2021) The role of risk communication in public health interventions. An analysis of risk communication for a community quarantine in Germany to curb the SARS-CoV-2 pandemic. PLOS One 16(8), e0256113.

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Vandewalle J, Timmermans S, Paakinaho V, Vancraeynest L, Dewyse L, Vanderhaeghen T, Wallaeys C, Van Wyngene L, Van Looveren K, Nuyttens L, Eggermont M, Dewaele S, Velho TR, Moita LF, Weis S, Sponholz C, van Grunsven LA, Dewerchin M, Carmeliet P, De Bosscher K, Van de Voorde J, Palvimo JJ, Libert C (2021) Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis. Cell Metab 33(9), 1763-1776.

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Weis S, Scherag A, Baier M, Kiehntopf M, Kamradt T, Kolanos S, Ankert J, Glöckner S, Makarewicz O, Hagel S, Bahrs C, Kimmig A, Proquitté H, Guerra J, Rimek D, Löffler B, Pletz MW (2021) Antibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study. Clin Microbiol Infect 27(3), 470.e1-470.e9.

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Winkler MS, Skirecki T, Brunkhorst FM, Cajander S, Cavaillon JM, Ferrer R, Flohé SB, García-Salido A, Giamarellos-Bourboulis EJ, Girardis M, Kox M, Lachmann G, Martin-Loeches I, Netea MG, Spinetti T, Schefold JC, Torres A, Uhle F, Venet F, Weis S, Scherag A, Rubio I, Osuchowski MF (2021) Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. EBioMedicine 66, 103291. (Review)

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Blankenhaus B, Braza F, Martins R, Bastos-Amador P, González-García I, Carlos AR, Mahu I, Faisca P, Nunes JM, Ventura P, Hoerr V, Weis S, Guerra J, Cardoso S, Domingos A, López M, Soares MP (2019) Ferritin regulates organismal energy balance and thermogenesis. Mol Metab 24, 64-79.

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Bauer M, Weis S, Netea MG, Wetzker R (2018) Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity. Trends Immunol 39(6), 438-445. (Review)

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Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schäuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell 169(7), 1263-1275.e14.

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Weis S, Hagel S, Schmitz RP, Scherag A, Brunkhorst FM, Forstner C, Löffler B, Pletz MW (2017) Study on the utility of a statewide counselling programme for improving mortality outcomes of patients with Staphylococcus aureus bacteraemia in Thuringia (SUPPORT): a study protocol of a cluster-randomised crossover trial. BMJ Open 7(4), e013976.

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