Antibiotics are an essential part of modern medicine. They form the basis for the treatment of life-threatening bacterial and fungal infectious diseases. The Transfer Group Antiinfectives identifies new, promising active substances and systematically advances their development into innovative drugs.

The Transfer Group Antiinfectives is an integral part of the InfectControl 2020 research network funded by the German Federal Ministry of Education and Research (BMBF). We receive further essential grants from the Free State of Thuringia and the German Centre for Infection Research (DZIF).

Team

Axel A. Brakhage
Acting Head
Sina Gerbach
Deputy Head

Drug development

Antibiotics research and development unites many disciplines. From the discovery of a new natural bioactive compound or a new biological target structure to the drug, approximately 15 years of research and development time are required even under ideal conditions. A modern laboratory infrastructure and a closely interacting team of scientists from different disciplines are crucial for efficient compund development.

Infrastructure

Effective and goal-oriented antibiotics research and development are inextricably linked to modern instrumental laboratory analytics. Mass spectrometric methods, biophysical and spectroscopic methods are of global importance.

The Transfer Group Antiinfectives is equipped with an extensive modern equipment park, which was financed by various public sponsors. To view the individual devices, please select the tabs above.

Publications

Barth SA, Preussger D, Pietschmann J, Feßler AT, Heller M, Herbst W, Schnee C, Schwarz S, Kloss F, Berens C, Menge C (2024) In vitro antibacterial activity of microbial natural products against bacterial pathogens of veterinary and zoonotic relevance. Antibiotics (Basel) 13(2), 135.
Jia LJ#, González K*, Orasch T*, Schmidt F*, Brakhage AA# (2024) Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities. Nat Microbiol 9(9), 2216-2231. (Review)
Keiff F, Bernal FA, Joch M, Jacques Dit Lapierre TJW, Li Y, Liebing P, Dahse HM, Vilotijevic I, Kloss F (2024) Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution. Commun Chem 7(1), 153.

Funding