Divergolide congeners illuminate alternative reaction channels for ansamycin diversification.

Ding L, Franke J, Hertweck C (2015) Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Org. Biomol. Chem. 13(6), 1618-1623.

Abstract

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

Leibniz-HKI-Authors

Ling Ding
Jakob Franke
Christian Hertweck

Identifier

doi: 10.1039/c4ob02244k

PMID: 25464499