(2021)
Direct visualization of fungal burden in filamentous fungus-infected silkworms.
J Fungi (Basel) 7(2),
136.
Prof. Dr. Axel A. Brakhage
Director Molecular and Applied Microbiology · Head of Department Transfer Group Antiinfectives · Acting head +49 3641 532-1001 axel.brakhage@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Professional Career
| since 2005 | Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) Jena |
| since 2005 | Head of Department Molecular and Applied Microbiology, Leibniz-HKI Jena |
| since 2004 | Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, Friedrich Schiller University Jena |
| 2001-2004 | Professor (C4) and chair in microbiology, Leibniz University Hanover |
| 1998-2001 | Professor (C3) in microbiology, Technical University Darmstadt |
| 1996 | Habilitation in microbiology, Ludwig-Maximilians-University Munich |
| 1992-1998 | Research assistant (C1), Institute for Genetics and Microbiology, Ludwig Maximilian University of Munich |
| 1990-1992 | Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG |
| 1989-1990 | Group head, Biotechnology, BASF AG, Ludwigshafen |
| 1989 | Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris |
| 1985 | Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster |
Awards · Appointments · Scientific Activities
| 2024 | Ferdinand Cohn-Medal of the German Society for Hygiene and Microbiology (DGHM) |
| since 2020 | Vice President of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) |
| since 2020 | Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina |
| since 2020 | Board of Directors, Leibniz Center for Photonics in Infection Research (LPI) |
| since 2020 | Founding member and Board of Directors "Incate" Incubator for Antibacterial Therapies in Europe |
| since 2019 | Member of the scientific panel of the Leibniz Institute of Virology (LIV), Hamburg |
| since 2019 | Member of the foundation board of the Leibniz Institute for Immunotherapy (LIT), Regensburg |
| 2019-2022 | Spokesperson of the Excellence Cluster "Balance of the Microverse" (DFG) |
| since 2018 | Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster |
| since 2017 | Member of the Steering Committee DZIF/TTU Novel Antibiotics |
| since 2017 | Elected member of the American Academy of Microbiology |
| since 2017 | Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin |
| since 2017 | Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK |
| since 2016 | Member of the Clusterboard RIS3 Thüringen |
| since 2016 | Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin |
| 2016-2020 | Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“ |
| since 2015 | Elected member of the European Academy of Microbiology |
| since 2015 | Honorary member of the Deutschsprachige Mykologische Gesellschaft e.V. (DMykG) |
| 2014 | Main Research Award of the German Society for Hygiene and Microbiology (DGHM) |
| since 2013 | Spokesperson of the SFB/Transregio 124 FungiNet (DFG) |
| 2013-2020 | Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology |
| since 2013 | Board member of the research campus “InfectoGnostics” (BMBF) |
| since 2012 | Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation” |
| 2012-2016 | Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
| 2010-2012 | Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena |
| 2010-2018 | Authorised commissioner of the Leibniz Association for Biotechnology |
| 2010-2018 | Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig |
| 2010-2018 | Member of the scientific panel of the Institute for Pharmaceutical Research (HIPS), Saarbrücken |
| 2010-2020 | Member of the scientific panel of the Research Centre Borstel, Borstel |
| 2010-2017 | Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle |
| 2009-2017 | Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig |
| 2009-2016 | Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg |
| 2009-2011 | President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM) |
| 2008-2019 | Member of the university council (reappointment 2011+2015) at the Friedrich Schiller University Jena |
| 2008-2016 | Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
| 2008 | Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina |
| 2007-2016 | Liaison Officer for scientific misconduct at the FSU Jena |
| 2007-2020 | Spokesperson of the excellence graduate school „Jena School for Microbial Communication” (JSMC) |
| 2006-2008 | Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“ |
| 2006 | Heinz-Seeliger award for infection biology |
| since 2005 | Scientific panel "Goettinger Center for Molecular Bio/Sciences" (GZMB), Georg-August-University Göttingen |
| 2005-2022 | Member of the Faculty Council of the Faculty of Biological Sciences, Friedrich Schiller University Jena |
| 2004-2010 | Representative of the DFG Priority Programme 1160 "Colonisation and Infection by Human-pathogenic Fungi" |
| 2003-2010 | Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark |
| 2003-2009 | Member in the programme committee of the DFG Priority Programme 1152 "Evolution of Metabolic Diversity" |
| 2003-2004 | Dean, faculty biology, Leibniz-University Hanover |
| 2002-2006, 2009-2020 |
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg |
| since 1998 | Editor of several magazines |
| since 1995 | Principal investigator in EU projects |
Publications
(2020)
Caspofungin functionalized polymethacrylates with antifungal properties.
Biomacromolecules 21(6),
2104-2115.
(2020)
Dynamic surface proteomes of allergenic fungal conidia.
J Proteome Res 19(5),
2092-2104.
(2020)
New avenues towards drug discovery in fungi.
In: The Mycota 2, pp. 267-295. Springer, Cham.
ISBN: 978-3-030-49923. (Review)
(2020)
The pheromone module SteC-MkkB-MpkB-SteD-HamE regulates development, stress responses and secondary metabolism in Aspergillus fumigatus.
Front Microbiol 11,
811.
(2020)
The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition.
Nucleic Acids Res 48(7),
3567-3590.
(2020)
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.
Nat Commun 11(1),
2282.
(2020)
Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages.
Environ Microbiol 22(9),
3722-3740.
(2020)
Structural basis of HapEP88L based antifungal triazole resistance in Aspergillus fumigatus.
Life Sci Alliance 3(7),
e202000729.
(2020)
Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection.
mSphere 5(4),
e00535-20.
