Publications

Fiedler J, Dumjahn L, Ishida-Ito M, Trottmann F, Ishida K, Hertweck C (2025) Thiotemplated polyketide chain fusion and reductive cyclization build the reactive butenolide core of malleicyprol. Angew Chem Int Ed 64(31), e202504485.
Dell M, Tran MA, Capper MJ, Sundaram S, Fiedler J, Koehnke J, Hellmich UA, Hertweck C (2024) Trapping of a polyketide synthase module after C-C bond formation reveals transient acyl carrier domain interactions. Angew Chem Int Ed 63(9), e202315850.
Ehinger FJ, Scherlach K, Trottmann F, Fiedler J, Richter I, Hertweck C (2024) A catch-release strategy for the genomics-driven discovery of antiproliferative furan-functionalized peptides. Angew Chem Int Ed 64(11), e202421760.
Fiedler J, Trottmann F, Ishida K, Mie II, Hertweck C (2024) Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway. Angew Chem Int Ed 63(30), e202405165.
Trottmann F, Fiedler J, Ishida K, Ishida-Ito M, Little RF, Hertweck C (2023) Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis. ACS Chem Biol 18(7), 1557-1563.
Kufs JE, Hoefgen S, Rautschek J, Bissell AU, Graf C, Fiedler J, Braga D, Regestein L, Rosenbaum MA, Thiele J, Valiante V (2020) Rational design of flavonoid production routes using combinatorial and precursor-directed biosynthesis. ACS Synth Biol 9(7), 1823-1832.