Héctor Torres-Gomez

Dr. Héctor Torres-Gomez

Transfer Group Anti-infectives

Phone: +49 3641 532-1297 Fax: +49 3641 532-2297 Email: hector.torres-gomez@leibniz-hki.de

Main Research Areas
Synthesis chemistry Drug Discovery
Curriculum vitae

Professional Career

Since 08.2019 Synthetic Medicinal Chemist Drug Discovery, Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany. Lead optimization of novel antimicrobials
04.2017-12.2018 Senior Research Scientist, Lecturer, Praktikumsleiter, Lab Manager, Prof. Dr. T. Kurz, Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany. Design and synthesis of novel inhibitors of epigenetic targets (BET and HDACs).
08.2014-09.2016 Postdoc, Collaboration between the Zürcher Hochschule für Angewandte Wissenchaften (ZHAW, Prof. R. Riedl) and the pharma startup Bacoba AG, Zürich, Switzerland. Hit-to-lead and lead optimization of novel antiparasitic compounds against Neglected Tropical Parasitic Diseases.
02.2014-07.2014 Research Associate, Prof. Dr. B. Wünsch, Institute for Pharmaceutical and Medicinal Chemistry. Westfälische Wilhelms-Universität, Münster, Germany.  Stereoselective synthesis of [4.3.3]propellan-8-amines as bioisosteres of amantadine.
10.2010-02.2014 Doctoral Project, Prof. Dr. B. Wünsch, Institute for Pharmaceutical and Medicinal Chemistry. Westfälische Wilhelms-Universität, Münster, Germany. Development of the [4.3.3]propellane moiety as a versatile scaffold for the design of bioactive molecules.
01.2010-10.2010 Research Assistant, Prof. Jaime Escalante, CIQ-UAEM, Cuernavaca, Mexico.  Stereoselective synthesis and enzymatic resolution of b2-tryptophane derivatives.
08.2007-11.2009 Master in Pharmacy, Prof. Gabriel Navarrete-Vázquez, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico. Design and synthesis of dual PPARα/γ agonists as potential agents for the treatment of metabolic diseases.
06.2006-07.2007 Bachelor in Chemistry, Thesis work at Prof. Gabriel Navarrete-Vázquez´s Lab, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico. Design and synthesis of novel Pentamidine-benzimidazole hybrids as potent antiprotozoal compounds.
Publications

Torres-Gómez H, Daniliuc C, Schepmann D, Wünsch B (2018) Synthesis of 3-aza[4.4.3]propellanes with high σ1 receptor affinity. Bioorg Med Chem 26(8), 1705-1712. Details PubMed

Abu Eid S, Adams M, Scherer T, Torres-Gómez H, Hackl MT, Kaplanian M, Riedl R, Luger A, Fürnsinn C (2017) Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents. Eur J Pharmacol 798, 77-84. Details PubMed

Navarrete-Vázquez G, Austrich-Olivares A, Godínez-Chaparro B, Hidalgo-Figueroa S, Estrada-Soto S, Hernández-Núñez E, Torres-Gómez H, Schepmann D, Wünsch B (2016) Discovery of 2-(3,4-dichlorophenoxy)-N-(2-morpholin-4-ylethyl)acetamide: A selective σ1 receptor ligand with antinociceptive effect. Biomed Pharmacother 79, 284-293. Details PubMed

Torres-Gómez H, Lehmkuhl K, Frehland B, Daniliuc C, Schepmann D, Ehrhardt C, Wünsch B (2015) Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines. Bioorg Med Chem 23(15), 4277-4285. Details PubMed

Bourgeois C, Werfel E, Galla F, Lehmkuhl K, Torres-Gómez H, Schepmann D, Kögel B, Christoph T, Straßburger W, Englberger W, Soeberdt M, Hüwel S, Galla HJ, Wünsch B (2014) Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists. J Med Chem 57(15), 6845-6860. Details PubMed

Navarrete-Vázquez G, Torres-Gómez H, Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Medina-Franco JL, León-Rivera I, Alarcón-Aguilar FJ, Almanza-Pérez JC (2014) Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect. Bioorg Med Chem Lett 24(18), 4575-4579. Details PubMed

Torres-Gómez H, Lehmkuhl K, Schepmann D, Wünsch B (2013) Design, synthesis and receptor affinity of novel conformationally restricted σ ligands based on the [4.3.3]propellane scaffold. Eur J Med Chem 70, 78-87. Details PubMed

Hernández-Núñez E, Tlahuext H, Moo-Puc R, Torres-Gómez H, Reyes-Martínez R, Cedillo-Rivera R, Nava-Zuazo C, Navarrete-Vazquez G (2009) Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles. Eur J Med Chem 44(7), 2975-2984. Details PubMed

Navarrete-Vázquez G, Torres-Gómez H, Hidalgo-Figueroa S, Tlahuext H (2008) 2-Methyl-2-(4-nitro-phen-oxy)propanoic acid. Acta Crystallogr Sect E Struct Rep Online 64(Pt 12), o2261. Details PubMed