Freddy Alexander Bernal

PhD Freddy Alexander Bernal

Transfer Group Anti-infectives +49 3641 532-1044

Curriculum vitae

Main Research Areas
  • Computer-Aided Drug Discovery
  • Organic Synthesis of Drug-like Antimicrobial Compounds
Professional Career
Since 09.2020 Chemist for Drug Discovery, Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI), Jena, Germany. Topic: Computer-aided discovery and optimization of novel antimicrobials.
08.2015-10.2019 Doctorate (Doctor of Natural Sciences – Pharmacy), Westfälische Wilhelms – Universität Münster, Münster, Germany. Dissertation title: Qualitative and quantitative structure-activity relationships on 2-phenyl-2,3-dihydrobenzofurans as Leishmanicidal agents. Research advisor: Prof. Dr. Thomas J. Schmidt
02.2012-05.2015 Research Assistant. Bioorganic Chemistry, Military University Nueva Granada, Cajicá, Colombia.
07.2011-05.2015 Lecturer, General Chemistry. Department of Chemistry, Military University Nueva Granada, Bogotá, Colombia.
08.2011-12.2013 Lecturer, Instrumental Analysis and Spectroscopy. Department of Educational Chemistry, Distrital University Francisco Jose de Caldas, Bogotá, Colombia.
02.2010-12.2010 Lecturer, Organic Chemistry and Analytical Chemistry. Technological Corporation of Bogota, Bogotá, Colombia.
08.2007-10.2009 Master in Sciences – Chemistry, National University of Colombia, Bogotá, Colombia. Thesis title: Isolation of secondary metabolites from the leaves of Iryanthera ulei Warb. (Myristicaceae), evaluation of their antimicrobial activity and synthesis of one 8-O-4′-neolignan. Research advisor: Prof. Dr. Luis E. Cuca.
02.2002-02.2007 Bachelor in Chemistry, National University of Colombia, Bogotá, Colombia.


Keiff F, Jacques dit Lapierrev TJW, Bernal F, Kloss F (2023) Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents. Arch Pharm (Weinheim) 356(11), e2300356.
Bernal FA, Coy-Barrera E (2022) Composition and antifungal activity of the alkaloidal fraction of Lupinus mirabilis leaves: A biochemometrics-based exploration. Molecules 27(9), 2832.
Bernal FA, Hammann P, Kloss F (2022) Natural products in antibiotic development: is the success story over? Curr Opin Biotechnol 78, 102783. (Review)
Schieferdecker S, Bernal FA, Wojtas KP, Keiff F, Li Y, Dahse HM, Kloss F (2022) Development of predictive classification models for whole cell antimycobacterial activity of benzothiazinones. J Med Chem 65(9), 6748-6763.
Bernal FA, Gerhards M, Kaiser M, Wünsch B, Schmidt TJ (2020) (±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis. Eur J Med Chem 205, 112493.
Bernal FA, Kaiser M, Wünsch B, Schmidt TJ (2020) Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents. ChemMedChem 15(1), 68-78.
Martin B, Schepmann D, Bernal FA, Schmidt TJ, Che T, Loser K, Wünsch B (2020) Enantiomerically pure quinoline-based κ-opioid receptor agonists: Chemoenzymatic synthesis and pharmacological evaluation. ChemMedChem 15(15), 1408-1420.
Sánchez-Suárez J, Bernal FA, Coy-Barrera E (2020) Colombian contributions fighting leishmaniasis: A systematic review on antileishmanials combined with chemoinformatics analysis. Molecules 25(23), 5704.
Bernal FA, Schmidt TJ (2019) A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues. Molecules 24(23),
Guerrero-Perilla C, Bernal FA, Coy-Barrera E (2018) Insights into the interaction and binding mode of a set of antifungal azoles as inhibitors of potential fungal enzyme-based targets. Mol Divers 22(4), 929-942.