Dr. Freddy Alexander Bernal

Transfer Group Anti-infectives

Phone: +49 3641 532-1044 Fax: +49 3641 532-2044 Email: freddy.bernal@leibniz-hki.de

Main Research Areas
Computer-Aided Drug Discovery

Organic Synthesis of Drug-like Antimicrobial Compounds
Curriculum vitae

Professional Career

Since 09.2020 Chemist for Drug Discovery, Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI), Jena, Germany. Topic: Computer-aided discovery and optimization of novel antimicrobials.
08.2015-10.2019 Doctorate (Doctor of Natural Sciences – Pharmacy), Westfälische Wilhelms – Universität Münster, Münster, Germany. Dissertation title: Qualitative and quantitative structure-activity relationships on 2-phenyl-2,3-dihydrobenzofurans as Leishmanicidal agents. Research advisor: Prof. Dr. Thomas J. Schmidt
02.2012-05.2015 Research Assistant. Bioorganic Chemistry, Military University Nueva Granada, Cajicá, Colombia.
07.2011-05.2015 Lecturer, General Chemistry. Department of Chemistry, Military University Nueva Granada, Bogotá, Colombia.
08.2011-12.2013 Lecturer, Instrumental Analysis and Spectroscopy. Department of Educational Chemistry, Distrital University Francisco Jose de Caldas, Bogotá, Colombia.
02.2010-12.2010 Lecturer, Organic Chemistry and Analytical Chemistry. Technological Corporation of Bogota, Bogotá, Colombia.
08.2007-10.2009 Master in Sciences – Chemistry, National University of Colombia, Bogotá, Colombia. Thesis title: Isolation of secondary metabolites from the leaves of Iryanthera ulei Warb. (Myristicaceae), evaluation of their antimicrobial activity and synthesis of one 8-O-4′-neolignan. Research advisor: Prof. Dr. Luis E. Cuca.
02.2002-02.2007 Bachelor in Chemistry, National University of Colombia, Bogotá, Colombia.
Publications

Bernal FA, Gerhards M, Kaiser M, Wünsch B, Schmidt TJ (2020) (±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis. Eur J Med Chem 205, 112493. Details PubMed

Bernal FA, Kaiser M, Wünsch B, Schmidt TJ (2020) Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents. ChemMedChem 15(1), 68-78. Details PubMed

Martin B, Schepmann D, Bernal FA, Schmidt TJ, Che T, Loser K, Wünsch B (2020) Enantiomerically pure quinoline-based κ-opioid receptor agonists: Chemoenzymatic synthesis and pharmacological evaluation. ChemMedChem 15(15), 1408-1420. Details PubMed Open Access PDF

Sánchez-Suárez J, Bernal FA, Coy-Barrera E (2020) Colombian contributions fighting leishmaniasis: A systematic review on antileishmanials combined with chemoinformatics analysis. Molecules 25(23), 5704. Details PubMed Open Access PDF

Bernal FA, Schmidt TJ (2019) A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues. Molecules 24(23), Details PubMed

Guerrero-Perilla C, Bernal FA, Coy-Barrera E (2018) Insights into the interaction and binding mode of a set of antifungal azoles as inhibitors of potential fungal enzyme-based targets. Mol Divers 22(4), 929-942. Details PubMed

Bernal FA, Orduz-Diaz LL, Coy-Barrera ED (2016) Application of PARAFAC and OPLS-DA analyses on HPLC fingerprints for the characterization of Hibiscus sabdariffa calyxes. Quim. Nova 39(2), 160-166. Details

Bernal FA, Orduz-Diaz LL, Guerrero-Perilla C, Coy-Barrera ED (2016) Diazo coupling reaction of catechins and alkylresorcinols with diazotized sulfanilic acid for quantitative purposes in edible sources: method development and validation. Food Analytical Methods 9(2), 411-418. Details

Bernal FA, Coy-Barrera E (2015) Molecular docking and multivariate analysis of xanthones as antimicrobial and antiviral agents. Molecules 20(7), 13165-13204. Details

Bernal FA, Coy-Barrera ED (2015) Chemical profile and antioxidant capacity of calyxes from commercial crops-derived Colombian Roselle (Hibiscus sabdariffa L.). Medicinal Plants - International Journal of Phytomedicines and Related Industries 7(2), 137-144. Details

Bernal FA, Cuca LE, Fadini L (2015) A Facile approach toward 8-O-4'-neolignans: synthesis of threo-7',8'-dihydromachilin D through Jacobsen epoxidation Revista Facultad de Ciencias Básicas 11(1), 114-129. Details

Bernal FA, Orduz-Diaz LL, Coy-Barrera E (2015) Exploitation of the complexation reaction of ortho-dihydroxylated anthocyanins with aluminum(III) for their quantitative spectrophotometric determination in edible sources. Food Chem 185, 84-89. Details PubMed

Bernal FA, Coy-Barrera E (2014) In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets. Molecules 19(5), 5550-5569. Details PubMed

Orduz-Diaz LL, Bernal FA, Coy-Barrera ED (2014) Diterpenos de núcleo kaurano como inhibidores de la PTR1 de Leishmania: un estudio in silico. Revista Facultad de Ciencias Básicas 9(1), 142-152. Details

Bernal FA, Cuca-Suárez LE, Yamaguchi LF, Coy-Barrera ED (2013) LC-DAD-UV and LC-ESI-MS-based analyses, antioxidant capacity, and antimicrobial activity of a polar fraction from Iryanthera ulei leaves. Records of Natural Products 7(2), 152-156. Details

Bernal FA, Delgado WA, Cuca LE (2012) Fingerprint analysis of unfractionated piper plant extracts by HPLC-UV-DAD coupled with chemometric methods. Journal of the Chilean Chemical Society 57(3), 1256-1261. Details

Bernal FA, Cuca LE (2009) Chemical constituents from Iryanthera ulei Warb. Biochemical Systematics and Ecology 37(6), 772-775. Details

Cuca LE, Bernal FA, Coy CA, Coy ED (2009) Essential oil composition and antimicrobial activity of fruits of Iryanthera ulei W. from Colombia. Journal of the Chilean Chemical Society 54(4), 289-291. Details