(2020)
Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptides.
Proc Natl Acad Sci U S A 117(38),
23802-23806.
Prof. Dr. Christian Hertweck
Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.deCurriculum vitae
Main Research Areas
- Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
- Use of enzymes and recombinant microorganisms for synthetic implementation
- Isolation and structural identification of natural products
- Molecular basis of fungus-bacteria-interactions
Professional Career
| 2011 | Call to ETH Zurich, declined |
| 2008 – 2023 | Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany |
| 2008 | Call to TU Munich, declined |
| Since 2006 | Head of Department of Biomolecular Chemistry, HKI Jena |
| Since 2006 | Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany |
| 2006 | Habilitation (Venia legendi) in organic chemistry, FSU Jena |
| 2005 | Call to Rheinische Friedrich Wilhelms University Bonn, declined |
| 2005 | Acceptance of professorship (W3), FSU Jena |
| 2001– 2005 | Head of junior research group, HKI Jena |
| 1999 – 2000 | Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation) |
| 1996 – 1999 | PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship |
| 1996 | Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany |
Awards · Appointments · Scientific Activities
| 2015 | Member of the National Academy of Sciences Leopoldina |
| 2015 | Gottfried Wilhelm Leibniz Award |
| 2015 | David Gottlieb Memorial Lecture Award, University of Illinois |
| 2014 | Wilhelm Manchot-Research Professor |
| Since 2013 | Member of the editorial board Bioorganic Chemistry |
| Since 2012 | Editor, Chemistry & Biology |
| Since 2012 | Member of the faculty of 1000 |
| Since 2011 | Member of the editorial board, Organic and Biomolecular Chemistry |
| Since 2011 | Member of the editorial board, Journal of Antibiotics |
| 2011 | NPR lecture award |
| Since 2010 | Member of the editorial board, ChemBioChem |
| 2009 – 2012 | Member of the editorial board, Chemistry & Biology |
| 2006 | Research prize of the Dr. Otto Röhm-Memorial-Foundation |
| Since 2005 | Member of the Association for General and Applied Microbiology (VAAM) |
| 2005 | DECHEMA award for natural product research |
| 2005 | Science award for life sciences and physics from the Beutenberg Campus Jena e.V. |
| 2005 | Thuringian research award (category: basic research) |
| Since 2003 | Member of the programme committee, Natural Product Meeting, Irsee |
| Since 2002 | Member of the DECHEMA Society for Chemical Engineering and Biotechnology |
| Since 2001 | Member of the Gesellschaft Deutscher Chemiker (GDCh) |
Publications
(2020)
Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins.
Chem Eur J 26(58),
13147-13151.
(2020)
Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria.
ISME J 14(11),
2794-2805.
(2020)
Injury-triggered blueing reactions of Psilocybe "magic" mushrooms.
Angew Chem Int Ed 59(4),
1450-1454.
(2020)
Induced production, synthesis and immunomodulatory action of clostrisulfone, a diarylsulfone from Clostridium acetobutylicum.
Chemistry 26(68),
15855-15858.
(2020)
Mining symbionts of spider-transmitted fungus illuminates uncharted biosynthetic pathways to cytotoxic benzolactones.
Angew Chem Int Ed 59(20),
7766-7771.
(2020)
Insect-associated bacteria assemble the antifungal butenolide gladiofungin by non-canonical polyketide chain termination.
Angew Chem Int Ed 59(51),
23122-23126.
(2020)
Chemical mediators at the bacterial-fungal interface.
Annu Rev Microbiol 74,
267-290.
(Review)
(2020)
Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin.
eLife 9,
e52541.
(2020)
Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor.
Angew Chem Int Ed 59(32),
13511-13515.
