
Dr. Keishi Ishida
Biomolecular Chemistry · Postdoc
Phone: +49 3641 532-1053 Fax: +49 3641 5320804 Email: keishi.ishida@leibniz-hki.de
(2020) Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins. Chem Eur J 26(58), 13147-13151. Details PubMed Open Access PDF
(2020) Induced production, synthesis and immunomodulatory action of clostrisulfone, a diarylsulfone from Clostridium acetobutylicum. Chemistry 26(68), 15855-15858. Details PubMed Open Access PDF
(2020) Insect-associated bacteria assemble the antifungal butenolide gladiofungin by non-canonical polyketide chain termination. Angew Chem Int Ed 59(51), 23122-23126. Details PubMed Open Access PDF
(2020) Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor. Angew Chem Int Ed 59(32), 13511-13515. Details PubMed Open Access PDF
(2019) Genome mining and heterologous expression reveal two distinct families of lasso peptides highly conserved in endofungal bacteria. ACS Chem Biol 15(5), 1169-1176. Details PubMed
(2019) Identification and mobilization of a cryptic antibiotic biosynthesis gene locus from a human-pathogenic nocardia isolate. ACS Chem Biol 15(5), 1161-1168. Details PubMed
(2019) Genomics-driven discovery of NO-donating diazeniumdiolate siderophores in diverse plant-associated bacteria. Angew Chem Int Ed 58(37), 13024-13029. Details PubMed Open Access PDF
(2019) Unique biosynthetic pathway in bloom-forming cyanobacterial genus Microcystis jointly assembles cytotoxic aeruginoguanidines and microguanidines. ACS Chem Biol 14(1), 67-75. Details PubMed
(2019) Loss of single domain function in modular assembly line alters size and shape of complex polyketide. Angew Chem Int Ed 58(50), 18252-18256. Details PubMed Open Access PDF
(2019) Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases. Nat Commun 10(1), 3918. Details PubMed Open Access PDF
(2019) Biosynthesis of diverse antimicrobial and antiproliferative acyloins in anaerobic bacteria. ACS Chem Biol 14(7), 1490-1497. Details PubMed
(2019) A pair of bacterial siderophores releases and traps an intercellular signal molecule: An unusual case of natural nitrone bioconjugation. Angew Chem Int Ed 58(1), 200-204. Details PubMed
(2019) Cyclopropanol warhead in malleicyprol confers virulence of human- and animal-pathogenic Burkholderia species. Angew Chem Int Ed 58(40), 14129-14133. Details PubMed Open Access PDF
(2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14(9), 841-843. Details PubMed
(2018) Enzymatic thioamide tormation in a bacterial antimetabolite pathway. Angew Chem Int Ed 57(36), 11574-11578. Details PubMed
(2017) High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Appl Environ Microbiol , Details PubMed
(2017) Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota. Cell Chem Biol 24(1), 66-75. Details PubMed
(2015) Plasticity of the Malleobactin Pathway and its Impact on Siderophore Action in Human Pathogenic Bacteria. Chemistry 21(22), 8010-8014. Details PubMed
(2015) Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proc Natl Acad Sci U S A 112(6), 1862-1867. Details PubMed
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details PubMed Open Access
(2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674. Details PubMed
(2015) Freedom and constraint in engineered noncolinear polyketide assembly lines Chem Biol 22(2), 229-240. Details PubMed
(2014) Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile. Org Lett 16(11), 2962-2965. Details PubMed
(2014) Evolution of siderophore pathways in human pathogenic bacteria. J Am Chem Soc 136(15), 5599-5602. Details PubMed
(2014) Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Appl Environ Microbiol 80(4), 1380-1387. Details PubMed
(2014) Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angew Chem Int Ed Engl 53(6), 1560-1564. Details PubMed
(2014) Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew Chem Int Ed Engl 53(14), 3735-3738. Details PubMed
(2013) Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis. Angew Chem Int Ed Engl 52(32), 8271-8275. Details PubMed
(2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51(10), 2425-2428. Details PubMed
(2012) Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. Angew Chem Int Ed Engl 51(22), 5470-5474. Details PubMed
(2012) Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. Chembiochem 13(15), 2196-2199. Details PubMed
(2012) Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Org Biomol Chem 10(30), 5756-5759. Details PubMed
(2011) A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environ Microbiol Rep 3(5), 550-558. Details PubMed
(2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40), 13966-13968. Details PubMed
(2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013. Details PubMed
(2010) Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl Environ Microbiol 76(11), 3568-3574. Details PubMed
(2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol 75(7), 2017-2026. Details PubMed
(2008) Orchestration of discoid polyketide cyclization in the resistomycin pathway. J Am Chem Soc 130(26), 8307-8316. Details PubMed
(2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol 26(2), 225-233. Details PubMed
(2008) Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl 47(40), 7756-7759. Details PubMed
(2008) Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl Environ Microbiol 74(6), 1791-1797. Details PubMed
(2007) Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chem Biol 14(5), 565-576. Details PubMed
(2007) Geminal tandem C-methylation in the discoid resistomycin pathway. J Am Chem Soc 129(42), 12648-12649. Details PubMed
(2007) Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem 8(13), 1577-1584. Details PubMed
(2007) Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Appl Environ Microbiol 73(3), 793-797. Details PubMed Open Access PDF
(2006) The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin. J Am Chem Soc 128(45), 14619-14624. Details PubMed