(2022)
A type III polyketide synthase specific for sporulating negativicutes is responsible for alkylpyrone biosynthesis.
ChemBioChem 23(21),
e202200431.
Publications
(2022)
Thiotemplated biosynthesis of bacterial polyyne fatty acids by a designated desaturase triad.
ChemBioChem 23(21),
e202200430.
(2022)
Sequential allylic alcohol formation by a multifunctional cytochrome P450 monooxygenase with rare redox partners.
Angew Chem Int Ed 61(26),
e202203264.
(2022)
Deciphering chemical mediators regulating specialized metabolism in a symbiotic cyanobacterium.
Angew Chem Int Ed 61(26),
e202204545.
(2022)
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat Chem 14(8),
884-890.
(2020)
Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins.
Chem Eur J 26(58),
13147-13151.
(2020)
Induced production, synthesis and immunomodulatory action of clostrisulfone, a diarylsulfone from Clostridium acetobutylicum.
Chemistry 26(68),
15855-15858.
(2020)
Insect-associated bacteria assemble the antifungal butenolide gladiofungin by non-canonical polyketide chain termination.
Angew Chem Int Ed 59(51),
23122-23126.
(2020)
Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor.
Angew Chem Int Ed 59(32),
13511-13515.
(2019)
Genome mining and heterologous expression reveal two distinct families of lasso peptides highly conserved in endofungal bacteria.
ACS Chem Biol 15(5),
1169-1176.
