(2025)
Thiotemplated polyketide chain fusion and reductive cyclization build the reactive butenolide core of malleicyprol.
Angew Chem Int Ed 64(31),
e202504485.
Topics
Publications
(2025)
Antibacterial siderophores of Pandoraea pathogens and their impact on the diseased lung microbiota.
Angew Chem Int Ed 64(24),
e202505714.
(2025)
Discovery and biosynthesis of celluxanthenes, antibacterial arylpolyene alkaloids from diverse cellulose-degrading anaerobic bacteria.
Angew Chem Int Ed 64(24),
e202503697.
(2025)
Mixing and matching of hybrid megasynthases is a hub for the evolution of metabolic diversity in cyanobacteria.
Angew Chem Int Ed 64(26),
e202502461.
(2024)
Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway.
Angew Chem Int Ed 63(30),
e202405165.
(2024)
An enzymatic prodrug-like route to thio and selenoamides.
Angew Chem Int Ed 63(31),
e202404243.
(2023)
Discovery and biosynthesis of the cytotoxic polyene terpenomycin in human pathogenic Nocardia.
ACS Chem Biol 18(8),
1872-1879.
(2023)
Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis.
ACS Chem Biol 18(7),
1557-1563.
(2022)
A type III polyketide synthase specific for sporulating negativicutes is responsible for alkylpyrone biosynthesis.
ChemBioChem 23(21),
e202200431.
(2022)
Thiotemplated biosynthesis of bacterial polyyne fatty acids by a designated desaturase triad.
ChemBioChem 23(21),
e202200430.
