(2004)
Rational saccharide extension by using the natural product glycosyltransferase LanGT4.
Chembiochem 5,
369-371.
Dirk Hoffmeister
Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.deCurriculum vitae
Main Research Areas
- Biochemical and genetic basis of fungal natural product biosyntheses
- Natural products of basidiomycetes and Ralstonia solanacearum
- Microbial nonribosomal peptide synthetases
Professional Career
2014- | Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena |
2009-2014 | Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena |
2007-2009 | Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA |
2008 | Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg |
2004-2007 | Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg |
2002-2004 | Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship) |
2002 | Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg |
1998 | Diploma in biology at the Eberhard-Karls-University, Tübingen |
Awards · Appointments · Scientific Activities
Since 2020 | Head of the Institute for Pharmacy, FSU Jena |
2016-2019 | Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena |
2013-2016 | Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM). |
Publications
(2004)
Structure-based enzyme engineering and its impact on in vitro glycorandomization.
Chembiochem 5,
16-25.
(2003)
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
J Am Chem Soc 125,
4678-4679.
(2003)
Creation of the first anomeric D/L-sugar kinase by means of directed evolution.
Proc Natl Acad Sci U S A 100,
13184-13189.
(2003)
Procaryotic and eucaryotic cells in biotech production
In: Kayser O, Müller R. H. (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications pp. 9-33. Wiley-Blackwell.
(2003)
Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.
FEMS Microbiol Lett 222,
149-153.
(2003)
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.
Chembiochem 4,
109-111.
(2002)
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.
Chem Biol 9,
287-295.
(2001)
Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.
Chem Biol 8,
557-567.
(2001)
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics.
Chem Biol 8,
569-581.