(2025)
Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043–02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.
Lancet Microbe 6(2),
100952.
Dr. Sina Gerbach
Research Coordination Transfer Group Antiinfectives · Project Management +49 3641 532-1335 sina.gerbach@leibniz-hki.deCurriculum vitae
Professional Career
| since 2016 | Scientific Coordinator, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany |
| 2011 - 2016 | Postdoc, Prof. P. Bastiaens, Max Planck Institute for Molecular Physiology, Dortmund, Germany, Activity of cMet during liver regeneration |
| 2009 - 2011 | Postdoc, Prof. L. Claesson-Welsh, Uppsala University, Sweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation. |
| 2008 | Postdoc, Prof. C. Thiede, University Hospital Dresden, Germany |
| 2003 - 2007 | PhD, Prof. C. Thiede, University Hospital Dresden, Germany, Receptor tyrosinkinase FLT3 in leukemic cells |
| 2002 | guest scientist, Prof. H. Sjöström, University of Copenhagen, Denmark |
| 2003 | Diploma in Biochemistry of Nutrition, University of Potsdam,G-protein-coupled receptor F2alpha |
| 1997 - 2003 | Studies in Science of Nutrition, University of Potsdam, Germany |
Topics
Publications
(2025)
The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis.
Nat Commun 16(1),
826.
(2018)
Hürden und Aussichten neuer antimikrobieller Konzepte in Forschung und Entwicklung. [Obstacles and perspectives of new antimicrobial concepts within research and development].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 61(5),
595-605.
(Review)
(2016)
In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions.
Methods Mol Biol 1447,
217-242.
(2014)
NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation.
Dev Cell 28(6),
633-646.
(2013)
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation.
Nat Commun 4,
1672.
(2013)
Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells.
J Cell Sci 126(Pt 20),
4746-4755.
(2013)
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
Exp Hematol 41(5),
444-461.e4.
(2012)
Neuropilin signalling in angiogenesis.
Biochem Soc Trans 40(1),
20-25.
(2012)
Signal transduction by vascular endothelial growth factor receptors.
Cold Spring Harb Perspect Med 2(7),
a006502.
