Dr. Sina Gerbach

Research Coordination Transfer Group Anti-infectives · Project Management +49 3641 532-1335 sina.gerbach@leibniz-hki.de

Curriculum vitae

Professional Career

since 2016	Scientific Coordinator, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany
2011 - 2016	Postdoc, Prof. P. Bastiaens, Max Planck Institute for Molecular Physiology, Dortmund, Germany, Activity of cMet during liver regeneration
2009 - 2011	Postdoc, Prof. L. Claesson-Welsh, Uppsala University, Sweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation.
2008	Postdoc, Prof. C. Thiede, University Hospital Dresden, Germany
2003 - 2007	PhD, Prof. C. Thiede, University Hospital Dresden, Germany, Receptor tyrosinkinase FLT3 in leukemic cells
2002	guest scientist, Prof. H. Sjöström, University of Copenhagen, Denmark
2003	Diploma in Biochemistry of Nutrition, University of Potsdam,G-protein-coupled receptor F2alpha
1997 - 2003	Studies in Science of Nutrition, University of Potsdam, Germany

Topics

INCATE

Publications

Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser M, Ryser M, Brenner S (2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol 38(3), 180-190.

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Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L (2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8), 1377-1388.

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Stölzel F, Steudel C, Oelschlägel U, Mohr B, Koch S, Ehninger G, Thiede C (2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol 89(7), 653-662.

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Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD (2009) Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 113(15), 3568-3576.

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Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN (2009) Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J 28(2), 57-65.

Details

Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C (2008) Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs 188(1-2), 225-235.

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Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, Ehninger G (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107(10), 4011-4020.

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Neuschäfer-Rube F, Engemaier E, Koch S, Böer U, Püschel GP (2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J 371(Pt 2), 443-449.

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