(2023)
Synthesis of aryl- and alkyl-containing 3-methylene-5-hydroxy esters via a barbier allylation reaction.
Eur J Org Chem 26(18),
e202300177.
Prof. Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head +49 3641 532-1525 christine.beemelmanns@leibniz-hki.deCurriculum vitae
Main Research Areas
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Characterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
| since 01/2022 | Professor of Biochemistry of Microbial Metabolism at the University of Leipzig |
| Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
| 2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
| 2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
| 2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
| 2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
| 2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
| 2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
| 2021 | Nachwuchswissenschaftler-Preise für Naturstoffforschung |
| 2020 | Dozentenpreis des Fonds der Chemischen Industrie |
| 2020 | Visiting Professor in Madison Wisconsin USA |
| 2019-2024 | ERC Starting GRant MORPHEUS |
| 2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
| Since 2014 | Membership VAAM, FEMS and IUMS |
| Since 2014 | Membership Dechema |
| Since 2014 | Membership National Research Foundation of Korea |
| 2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
| 2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
| 2010-2011 | Postdoc fellowship from the DAAD |
| Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
| 2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
| 2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
| 2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
| 2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
| 2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
| 2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
| Since 2003 | Member of the GDCH |
| 2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
| 2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
Publications
(2023)
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin.
Mol Ecol
[Epub ahead of print]
(2023)
Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies.
ISME J 17(5),
733-747.
(2023)
Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi.
Commun Chem 6(1),
79.
(2022)
Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.
ACS Chem Biol 17(2),
386-394.
(2022)
Synthesis of functionalized δ-hydroxy-β-keto esters and evaluation of their anti-inflammatory properties.
ChemBioChem 23(9),
e202200073.
(2022)
Insights into the metabolomic capacity of podaxis and isolation of podaxisterols A-D, ergosterol derivatives carrying nitrosyl cyanide-derived modifications.
J Nat Prod 85(9),
2159-2167.
(2022)
Signalling molecules inducing metamorphosis in marine organisms.
Nat Prod Rep 39(9),
1833-1855.
(Review)
(2022)
Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition.
Microbiol Spectr 10(5),
e0133122.
(2022)
Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites.
mSystems 7(1),
e0121421.
