We focus on Armillaria, Aspergillus and other fungi producing natural compounds
The associated Research Group Pharmaceutical Microbiology with its natural product-oriented research program links the Institute of Pharmacy at the Friedrich Schiller University with the Hans Knöll Institute. The group focuses on the genetic and biochemical basis of microbial secondary metabolite biosynthesis and on the discovery of novel, bioactive substances. Further, the group is a member of the Cooperative Research Center ChemBioSys in the Graduate School Jena School for Microbial Communication JSMC as well as in the International Leibniz Research School ILRS Mibintact.
Currently, research on the basidiomycetes (mushroom-type fungi) is emphasized. They are investigated using selected model species and genera, including Armillaria, Ceriporiopsis, Psilocybe, and Serpula. The basidiomycetes represent a group of organisms that has received little attention yet regarding its biosynthetic pathways. Once focus area is to understand the function of the natural products. Work in the group also aims at integrating chemistry and biology to use genomic data to predict natural product classes in silico.
Further projects include natural product biosyntheses in the Gram-negative bacterium Ralstonia solanacearum and in Aspergilli.