Keishi Ishida

Dr. Keishi Ishida

Biomolekulare Chemie · Postdoc

Telefon: +49 3641 532-1053 Telefax: +49 3641 5320804 E-Mail: keishi.ishida@leibniz-hki.de

Publikationen

Bratovanov EV, Ishida K, Heinze B, Pidot SJ, Stinear TP, Hegemann JD, Marahiel MA, Hertweck C (2019) Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria. ACS Chem Biol , Details PubMed

Herisse M, Ishida K, Porter JL, Howden B, Hertweck C, Stinear TP, Pidot SJ (2019) Identification and mobilization of a cryptic antibiotic biosynthesis gene locus from a human-pathogenic Nocardia isolate. ACS Chem Biol , Details PubMed

Hermenau R, Mehl JL, Ishida K, Dose B, Pidot SJ, Stinear TP, Hertweck C (2019) Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria. Angew Chem Int Ed 58(37), 13024-13029. Details PubMed

Pancrace C, Ishida K, Briand E, Gatte Pichi D, Weiz AR, Guljamow A, Scalvenzi T, Sassoon N, Hertweck C, Dittmann E, Gugger M (2019) A Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines. ACS Chem Biol 14(1), 67-75. Details PubMed

Peng H, Ishida K, Hertweck C (2019) Loss of Single Domain Function in Modular Assembly Line Alters Size and Shape of Complex Polyketide. Angew Chem Int Ed Engl , Details PubMed

Peng H, Ishida K, Sugimoto Y, Jenke-Kodama H, Hertweck C (2019) Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases. Nat Commun 10(1), 3918. Details PubMed

Schieferdecker S, Shabuer G, Letztel A-C, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C (2019) Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria. ACS Chem Biol 14(7), 1490-1497. Details PubMed

Trottmann F, Franke J, Ishida K, Garcia-Altares M, Hertweck C (2019) A pair of bacterial siderophores releases and traps an intercellular signal molecule: An unusual case of natural nitrone bioconjugation. Angew Chem Int Ed 58(1), 200-204. Details PubMed PDF

Trottmann F, Franke J, Richter I, Ishida K, Cyrulies M, Dahse HM, Regestein L, Hertweck C (2019) Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species. Angew Chem Int Ed Engl 58(40), 14129-14133. Details PubMed

Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C (2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14(9), 841-843. Details PubMed

Litomska A, Ishida K, Dunbar KL, Boettger M, Coyne S, Hertweck C (2018) Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway. Angew Chem Int Ed 57(36), 11574-11578. Details PubMed

Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E (2017) High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Appl Environ Microbiol , Details PubMed

Shao Y, Chen B, Sun C, Ishida K, Hertweck C, Boland W (2017) Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota. Cell Chem Biol 24(1), 66-75. Details PubMed

Franke J, Ishida K, Hertweck C (2015) Plasticity of the Malleobactin Pathway and its Impact on Siderophore Action in Human Pathogenic Bacteria. Chemistry 21(22), 8010-8014. Details PubMed

Liaimer A, Helfrich EJ, Hinrichs K, Guljamow A, Ishida K, Hertweck C, Dittmann E (2015) Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proc Natl Acad Sci U S A 112(6), 1862-1867. Details PubMed

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674. Details PubMed

Sugimoto Y, Ishida K, Traitcheva N, Busch B, Dahse HM, Hertweck C (2015) Freedom and constraint in engineered noncolinear polyketide assembly lines Chem Biol 22(2), 229-240. Details PubMed

Cai X, Ng K, Panesar H, Moon SJ, Paredes M, Ishida K, Hertweck C, Minehan TG (2014) Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile. Org Lett 16(11), 2962-2965. Details PubMed

Franke J, Ishida K, Hertweck C (2014) Evolution of siderophore pathways in human pathogenic bacteria. J Am Chem Soc 136(15), 5599-5602. Details PubMed

Gatte-Picchi D, Weiz A, Ishida K, Hertweck C, Dittmann E (2014) Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Appl Environ Microbiol 80(4), 1380-1387. Details PubMed

Sugimoto Y, Ding L, Ishida K, Hertweck C (2014) Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angew Chem Int Ed Engl 53(6), 1560-1564. Details PubMed

Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr JC, Müller KM, Groll M, Hertweck C, Dittmann E (2014) Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew Chem Int Ed Engl 53(14), 3735-3738. Details PubMed

Franke J, Ishida K, Ishida-Ito M, Hertweck C (2013) Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis. Angew Chem Int Ed Engl 52(32), 8271-8275. Details PubMed

Behnken S, Lincke T, Kloss F, Ishida K, Hertweck C (2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51(10), 2425-2428. Details PubMed

Ishida K, Lincke T, Hertweck C (2012) Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. Angew Chem Int Ed Engl 51(22), 5470-5474. Details PubMed

Richter M, Busch B, Ishida K, Moore BS, Hertweck C (2012) Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. Chembiochem 13(15), 2196-2199. Details PubMed

Scherlach K, Brendel N, Ishida K, Dahse HM, Hertweck C (2012) Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Org Biomol Chem 10(30), 5756-5759. Details PubMed

Liaimer A, Jenke-Kodama H, Ishida K, Hinrichs K, Stangeland J, Hertweck C, Dittmann E (2011) A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environ Microbiol Rep 3(5), 550-558. Details PubMed

Ishida K, Lincke T, Behnken S, Hertweck C (2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40), 13966-13968. Details PubMed

Lincke T, Behnken S, Ishida K, Roth M, Hertweck C (2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013. Details PubMed

Ziemert N, Ishida K, Weiz A, Hertweck C, Dittmann E (2010) Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl Environ Microbiol 76(11), 3568-3574. Details PubMed

Ishida K, Welker M, Christiansen G, Cadel-Six S, Bouchier C, Dittmann E, Hertweck C, Tandeau de Marsac N (2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol 75(7), 2017-2026. Details PubMed

Fritzsche K, Ishida K, Hertweck C (2008) Orchestration of discoid polyketide cyclization in the resistomycin pathway. J Am Chem Soc 130(26), 8307-8316. Details PubMed

Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol 26(2), 225-233. Details PubMed

Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E (2008) Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl 47(40), 7756-7759. Details PubMed

Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E (2008) Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl Environ Microbiol 74(6), 1791-1797. Details PubMed

Ishida K, Christiansen G, Yoshida WY, Kurmayer R, Welker M, Valls N, Bonjoch J, Hertweck C, Börner T, Hemscheidt T, Dittmann E (2007) Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chem Biol 14(5), 565-576. Details PubMed

Ishida K, Fritzsche K, Hertweck C (2007) Geminal tandem C-methylation in the discoid resistomycin pathway. J Am Chem Soc 129(42), 12648-12649. Details PubMed

Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M (2007) Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem 8(13), 1577-1584. Details PubMed

Partida-Martinez LP, de Looss CF, Ishida K, Ishida M, Roth M, Buder K, Hertweck C (2007) Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Appl Environ Microbiol 73(3), 793-797. Details PubMed Open Access PDF

Ishida K, Maksimenka K, Fritzsche K, Scherlach K, Bringmann G, Hertweck C (2006) The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin. J Am Chem Soc 128(45), 14619-14624. Details PubMed