Mikrobielle Pathogenitätsmechanismen

Arekar T, Katikaneni D, Kasem S, Desai D, Acharya T, Cole A, Khodayari N, Vaulont S, Hube B, Nemeth E, Drakesmith A, Lionakis MS, Mehrad B, Scindia Y (2025) Essential role of hepcidin in host resistance to disseminated candidiasis. Cell Rep 44(5), 115649.

Bègue H, Ducreux A, Paradis T, Loiselet A, Mourer T, Lucchi G, Kieffer-Jaquinod S, Coute Y, Hube B, Theodorou I, Thenet S, Gillet B, Hughes S, Lapaquette P, Basmaciyan L, Bachellier-Bassi S, d'Enfert C, Bon F, Dalle F (2025) Candida albicans releases a peptide from the Rbt1 protein to promote its invasion into the gut epithelium. Gut Microbes 17(1), 2573038.

Chang TH, Cardona Gloria Y, Hellmann MJ, Richardo T, Greve CL, Le Roy D, Roger T, Bork F, Bugl S, Jakob J, Sonnberger J, Kasper L, Hube B, Pusch S, Gow NAR, Sørlie M, Tøndervik A, Moerschbacher BM, Weber ANR (2025) Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing. Front Immunol 16, 1497174.

Fróis-Martins R, Lagler J, Schille TB, Elshafee O, Martinez de San Vicente K, Mertens S, Stokmaier M, Kilb I, Sertour N, Bachellier-Bassi S, Mogavero S, Sanglard D, d'Enfert C, Hube B, LeibundGut-Landmann S (2025) Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice. Nat Microbiol 10(10), 2472-2485.

Garbe E, Schäuble S, Böttcher B, Jesse R, Driesch D, van Wilijck L, Elshafee O, Schille TB, Hube B, Panagiotou^# G,Vylkova S (2025) A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism in Candida albicans mSystems [Accepted]

Hitzler SUJ, Fernández-Fernández C, Günther K, Dietschmann A, Hovhannisyan H, Möslinger A, Austermeier S, Cristóvão B, Vascelli G, Zelante T, Pekmezović M, Ramírez-Zavala B, Morschhäuser J, Werz O, Gabaldón T, Jordan PM, Vylkova S, Gresnigt MS (2025) Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway. Nat Commun 16(1), 6447.

Lange T, Sprague JL, Vij R, Alonso-Roman R, Jablonowski N, Radosa S, Krüger T, Kniemeyer O, Hillmann F, Brakhage AA, Allert S, Brunke S, Hube B (2025) "Pour some sugar on me"-Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation. PLoS Pathog 21(10), e1013542.

Lee S, Tsavou A, Zarnowski R, Pforte R, Allert S, Krüger T, Kniemeyer O, Brakhage AA, Bui TTT, Andes DR, Richardson JP, Hube B, Naglik JR (2025) Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses. Infect Immun 93(5), e0040424.

Lortal L, Lyon CM, Sprague JL, Sonnberger J, Paulin OKA, Wickramasinghe DN, Richardson JP, Hube B, Naglik JR (2025) Candidalysin biology and activation of host cells. mBio 16(11), e0060324. (Review)