Microbial Pathogenicity Mechanisms

Arekar T, Katikaneni D, Kasem S, Desai D, Acharya T, Cole A, Khodayari N, Vaulont S, Hube B, Nemeth E, Drakesmith A, Lionakis MS, Mehrad B, Scindia Y (2025) Essential role of hepcidin in host resistance to disseminated candidiasis. Cell Rep 44(5), 115649.

Chang TH, Cardona Gloria Y, Hellmann MJ, Richardo T, Greve CL, Le Roy D, Roger T, Bork F, Bugl S, Jakob J, Sonnberger J, Kasper L, Hube B, Pusch S, Gow NAR, Sørlie M, Tøndervik A, Moerschbacher BM, Weber ANR (2025) Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing. Front Immunol 16, 1497174.

Lee S, Tsavou A, Zarnowski R, Pforte R, Allert S, Krüger T, Kniemeyer O, Brakhage AA, Bui TTT, Andes DR, Richardson JP, Hube B, Naglik JR (2025) Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses. Infect Immun 93(5), e0040424.

Lortal L, Lyon CM, Sprague JL, Sonnberger J, Paulin OKA, Wickramasinghe DN, Richardson JP, Hube B, Naglik JR (2025) Candidalysin biology and activation of host cells. mBio [Epub ahead of print] (Review)

Makambi WK, Chiu VL, Kasper L, Hube B, Karlsson AJ (2025) Role of amino acid substitutions on proteolytic stability of histatin 5 in the presence of secreted aspartyl proteases and salivary proteases. Protein Sci 34(1), e70011.

Maneira C, Chamas A, Lackner G (2025) Engineering Saccharomyces cerevisiae for medical applications. Microb Cell Fact 24(1), 12. (Review)

Rosati D, Valentine M, Bruno M, Pradhan A, Dietschmann A, Jaeger M, Leaves I, van de Veerdonk FL, Joosten LAB, Roy S, Stappers MHT, Gow NAR, Hube B, Brown AJP, Gresnigt MS, Netea MG (2025) Lactic acid in the vaginal milieu modulates the Candida-host interaction. Virulence 16(1), 2451165.

Schille TB, Sprague JL, Naglik JR, Brunke S, Hube B (2025) Commensalism and pathogenesis of Candida albicans at the mucosal interface. Nat Rev Microbiol [Epub ahead of print] (Review)

Valentine M, Rosati D, Dietschmann A, Schille TB, Netea MG, Hube B, Gresnigt MS (2025) Probiotic Lactobacillus species modulate immune responses during vaginal epithelial cell colonization. J Infect Dis , jiaf221.