Microbial Pathogenicity Mechanisms

Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P (2023) Ecological niche-inspired genome mining leads to the discovery of crop-protecting nonribosomal lipopeptides featuring a transient amino acid building block. J Am Chem Soc [In press]

Schwarz C, Eschenhagen P, Schmidt H, Hohnstein T, Iwert C, Grehn C, Roehmel J, Steinke E, Stahl M, Lozza L, Tikhonova E, Rosati E, Stervbo U, Babel N, Mainz JG, Wisplinghoff H, Ebel F, Jia LJ, Blango MG, Hortschansky P, Brunke S, Hube B, Brakhage AA, Kniemeyer O, Scheffold A, Bacher P (2023) Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis. J Clin Invest , e161593.

Allert S, Schulz D, Kämmer P, Großmann P, Wolf T, Schäuble S, Panagiotou G, Brunke S, Hube B (2022) From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris. Virulence 13(1), 191-214.

Alonso-Roman R, Last A, Mirhakkak MH, Sprague JL, Möller L, Großmann P, Graf K, Gratz R, Mogavero S, Vylkova S, Panagiotou G, Schäuble S, Hube B, Gresnigt MS (2022) Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity. Nat Commun 13(1), 3192.

Declas N, Maynard JRJ, Menin L, Gasilova N, Götze S, Sprague JL, Stallforth P, Matile S, Waser J^* (2022) Tyrosine bioconjugation with hypervalent iodine. Chem Sci 13(43), 12808-12817.

García-Díaz M, Cendra MDM, Alonso-Roman R, Urdániz M, Torrents E, Martínez E (2022) Mimicking the intestinal host-pathogen interactions in a 3D in vitro model: The role of the Mucus layer. Pharmaceutics 14(8), 1552.

Gómez AC, Lyons T, Mamat U, Yero D, Bravo M, Daura X, Elshafee O, Brunke S, Gahan CGM, O'Driscoll M, Gibert I, O'Sullivan TP (2022) Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens. Eur J Med Chem 242, 114678.

Lapaquette P, Ducreux A, Basmaciyan L, Paradis T, Bon F, Bataille A, Winckler P, Hube B, d'Enfert C, Esclatine A, Dubus E, Bringer MA, Morel E, Dalle F (2022) Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans. Gut Microbes 14(1), 2004798.

Li XV, Leonardi I, Putzel GG, Semon A, Fiers WD, Kusakabe T, Lin WY, Gao IH, Doron I, Gutierrez-Guerrero A, DeCelie MB, Carriche GM, Mesko M, Yang C, Naglik JR, Hube B, Scherl EJ, Iliev ID (2022) Immune regulation by fungal strain diversity in inflammatory bowel disease. Nature 603(7902), 672-678.

Mogavero S, Höfs S, Lauer AN, Müller R, Brunke S, Allert S, Gerwien F, Groth S, Dolk E, Wilson D, Gutsmann T, Hube B (2022) Candidalysin is the hemolytic factor of Candida albicans. Toxins (Basel) 14(12), 874.