Interaction of Aspergillus fumigatus with human leukocytes

Aspergillus fumigatus is a pathogen that can cause severe infections in immunosuppressed patients. Phagocytosis is one of the main mechanisms of immune defense. This project investigates Host-Pathogen-Interactions of leukocytes and A. fumigatus, looking at adhesion, phagocytosis-rate, virulence and immune-evasion. In a sub-project, mutants of A. fumigatus with defects in GPI-anchored surface molecules or with defects in secondary metabolic pathways are characterized regarding their interaction with human leukocytes.

Flow cytometric assessment of phagocytosis of A. fumigatus by human leukocytes. Assay scheme and application in HSCT-patients and A. fumigatus mutant strains.
Mitarbeiter
Susann Hartung

Dr. Susann Hartung

Post-doc

Phone: +49 3641 532-1061 Email: susann.hartung@leibniz-hki.de

Mai Hoang

Mai Hoang

Ph.D. student

Phone: +49 3641 532-1541 Email: mai.hoang@leibniz-hki.de

Ava Kiesewetter

Ava Kiesewetter

technical assistant

Phone: +49 3641 532-1578 Email: ava.kiesewetter@leibniz-hki.de