Interaction of Aspergillus fumigatus with human leukocytes

Flow cytometric assessment of phagocytosis of A. fumigatus by human leukocytes. Assay scheme and application in HSCT-patients and A. fumigatus mutant strains.

Aspergillus fumigatus is a pathogen that can cause severe infections in immunosuppressed patients. Phagocytosis is one of the main mechanisms of immune defense. This project investigates Host-Pathogen-Interactions of leukocytes and A. fumigatus, looking at adhesion, phagocytosis-rate, virulence and immune-evasion. In a sub-project, mutants of A. fumigatus with defects in GPI-anchored surface molecules or with defects in secondary metabolic pathways are characterized regarding their interaction with human leukocytes.


Susann Hartung