(2025)
Rapid detection of microbial antibiotic susceptibility via deep learning supported analysis of angle-resolved scattered-light images of picoliter droplet cultivations.
Sens Actuators B Chem 424,
136866.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
since 2023 | Editor: PLOS Complex Systems |
since 2023 | Editor: Biological Imaging |
since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
since 2019 | Editor: Scientific Reports |
since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
since 2017 | Editor: Cytometry A |
since 2015 | Member: Jena Center for Soft Matter |
since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2024)
The proteomic response of Aspergillus fumigatus to Amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance.
microLife
[Accepted]
(2024)
Organ-on-chip models for infectious disease research.
Nat Microbiol 9(4),
891-904.
(Review)
(2024)
Engineering adhesion of the probiotic strain Escherichia coli nissle to the fungal pathogen Candida albicans.
ACS Synth Biol
[Epub ahead of print]
(2024)
Selective uptake into inflamed human intestinal tissue and immune cell targeting by wormlike polymer micelles.
Small 20(21),
2470162.
(2024)
Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages.
Immunology 173(4),
748-767.
(2024)
The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism.
mBio 15(3),
e0019524.
(2024)
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.
Biomaterials 307,
122525.
(2024)
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model.
Front Immunol 15,
1432307.
(2024)
NFDI4BIOIMAGE - National research data infrastructure for microscopy and bioimage analysis.
Zenodo ,
10.3389/fimmu.2024.1432307.