Microbial interactions

Natural products play a key role in symbiotic interactions between microorganisms and higher organisms, ranging from mutualism to pathogenesis. Using biological techniques and state-of-the-art analytical methods such as imaging techniques, we study the molecular basis of microbial communication in various ecosystems. The benefit for medical research is twofold: the compounds involved may serve as antibiotics, which can be further developed for human therapy, and the elucidation of virulence factors contributes to the understanding and cure of infectious diseases.


Christian Hertweck


Mirhakkak MH*, Chen X*, Heinekamp T, Sae-Ong T, Xu LL, Ni Y, Kurzai O, Barber AE, Brakhage AA, Boutin S, Schäuble S#, Panagiotou G# (2023) Genome-scale Metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome. Nat Commun 14(1), 4369.