Search for new antiinfectives through laboratory automation

In an increasingly globalized world, we are confronted with continuously growing challenges in the fight against infectious diseases. Antibiotic resistance and newly emerging pathogens pose a significant threat to human health. Our research group has set the goal of discovering new antiinfectives by utilizing state-of-the-art laboratory automation techniques in combination with specific assays and comprehensive data analyses.

 

The research group RoboThür ("Robotics-assisted Identification and Development of New Antiinfectives") is integrated into the structural unit for Robotics-assisted Discovery of Anti-infectives. This project is a close collaboration between the Friedrich Schiller University Jena and the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute. It is funded by the Free State of Thuringia with resources from the European Social Fund Plus (ESF+).

Team

Luzia Gyr
Head

Infrastructure

Publications

Walter K, Römpp A, Treu A, Kokesch-Himmelreich J, Marwitz F, Dreisbach J, Aboutara N, Hillemann D, Garrelts M, Converse P, Tyagi S, Gerbach S, Gyr L, Lemm AK, Volz J, Hölscher A, Gröschel L, Stemp EM, Heinrich N, Kloss F, Nuermberger E, Schwudke D, Hoelscher M, Hölscher C (2025) The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis. Nat Commun 16(1), 826.