(2022)
A type III polyketide synthase specific for sporulating negativicutes is responsible for alkylpyrone biosynthesis.
Chembiochem ,
e202200431.
Prof. Dr. Christian Hertweck
Deputy Director Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.deCurriculum vitae
Main Research Areas
- Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
- Use of enzymes and recombinant microorganisms for synthetic implementation
- Isolation and structural identification of natural products
- Molecular basis of fungus-bacteria-interactions
Professional Career
| 2011 | Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland |
| Since 2008 | Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany |
| 2008 | Rejection of professorship, Technical University Munich, Germany |
| Since 2006 | Head of Department of Biomolecular Chemistry, HKI Jena |
| Since 2006 | Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany |
| 2006 | Habilitation (Venia legendi) in organic chemistry, FSU Jena |
| 2005 | Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany |
| 2005 | Acceptance of professorship (W3), FSU Jena |
| 2001 - 2005 | Head of junior research group, HKI Jena |
| 1999 - 2000 | Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation) |
| 1996 - 1999 | PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship |
| 1996 | Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany |
Awards · Appointments · Scientific Activities
| 2015 | Member of the National Academy of Sciences Leopoldina |
| 2015 | Gottfried Wilhelm Leibniz Award |
| 2015 | David Gottlieb Memorial Lecture Award, University of Illinois |
| 2014 | Wilhelm Manchot-Research Professor |
| Since 2013 | Member of the editorial board Bioorganic Chemistry |
| Since 2012 | Editor, Chemistry & Biology |
| Since 2012 | Member of the faculty of 1000 |
| Since 2011 | Member of the editorial board, Organic and Biomolecular Chemistry |
| Since 2011 | Member of the editorial board, Journal of Antibiotics |
| 2011 | NPR lecture award |
| Since 2010 | Member of the editorial board, ChemBioChem |
| 2009 - 2012 | Member of the editorial board, Chemistry & Biology |
| 2006 | Research prize of the Dr. Otto Röhm-Memorial-Foundation |
| Since 2005 | Member of the Association for General and Applied Microbiology (VAAM) |
| 2005 | DECHEMA award for natural product research |
| 2005 | Science award for life sciences and physics from the Beutenberg Campus Jena e.V. |
| 2005 | Thuringian research award (category: basic research) |
| Since 2003 | Member of the programme committee, Natural Product Meeting, Irsee |
| Since 2002 | Member of the DECHEMA Society for Chemical Engineering and Biotechnology |
| Since 2001 | Member of the Gesellschaft Deutscher Chemiker (GDCh) |
Publications
(2022)
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature.
Nat Prod Rep 39(3),
453-459.
(Review)
(2022)
Cervimycin-resistant Staphylococcus aureus strains display Vancomycin-intermediate resistant phenotypes.
Microbiol Spectr
[Epub ahead of print]
(2022)
A specialized polythioamide-binding protein confers antibiotic self-resistance in anaerobic bacteria.
Angew Chem Int Ed 61(37),
e202206168.
(2022)
Sustainable and highly controlled aryl couplings revealed by systematic assessment of photoactivatable linkers.
Chemical Science 13(19),
5680-5686.
(2022)
A photochemical macrocyclization route to asymmetric strained [3.2]paracyclophanes.
Chemistry ,
(2022)
Alternative benzoxazole assembly discovered in anaerobic bacteria provides access to privileged heterocyclic scaffold.
Angew Chem Int Ed 61(32),
e202205409.
(2022)
Bacterial ectosymbionts in cuticular organs chemically protect a beetle during molting stages.
ISME J ,
(2022)
Thiotemplated biosynthesis of bacterial polyyne fatty acids by a designated desaturase tiad.
Chembiochem ,
(2022)
Sequential allylic alcohol formation by a multifunctional cytochrome P450 monooxygenase with rare redox partners.
Angew Chem Int Ed 61(26),
e202203264.
