Christian Hertweck

Prof. Dr. Christian Hertweck

Deputy Director Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
  • Use of enzymes and recombinant microorganisms for synthetic implementation
  • Isolation and structural identification of natural products
  • Molecular basis of fungus-bacteria-interactions
Professional Career
2011 Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland
Since 2008 Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany
2008 Rejection of professorship, Technical University Munich, Germany
Since 2006 Head of Department of Biomolecular Chemistry, HKI Jena
Since 2006 Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany
2006 Habilitation (Venia legendi) in organic chemistry, FSU Jena
2005 Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany
2005 Acceptance of professorship (W3), FSU Jena
2001 - 2005 Head of junior research group, HKI Jena
1999 - 2000 Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation)
1996 - 1999 PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship
1996 Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany
Awards · Appointments · Scientific Activities
2015 Member of the National Academy of Sciences Leopoldina
2015 Gottfried Wilhelm Leibniz Award
2015 David Gottlieb Memorial Lecture Award, University of Illinois
2014 Wilhelm Manchot-Research Professor
Since 2013 Member of the editorial board Bioorganic Chemistry
Since 2012 Editor, Chemistry & Biology
Since 2012 Member of the faculty of 1000
Since 2011 Member of the editorial board, Organic and Biomolecular Chemistry
Since 2011 Member of the editorial board, Journal of Antibiotics
2011 NPR lecture award
Since 2010 Member of the editorial board, ChemBioChem
2009 - 2012 Member of the editorial board, Chemistry & Biology
2006 Research prize of the Dr. Otto Röhm-Memorial-Foundation
Since 2005 Member of the Association for General and Applied Microbiology (VAAM)
2005 DECHEMA award for natural product research
2005 Science award for life sciences and physics from the Beutenberg Campus Jena e.V.
2005 Thuringian research award (category: basic research)
Since 2003 Member of the programme committee, Natural Product Meeting, Irsee
Since 2002 Member of the DECHEMA Society for Chemical Engineering and Biotechnology
Since 2001 Member of the Gesellschaft Deutscher Chemiker (GDCh)

Topics

Publications

Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E (2017) High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Appl Environ Microbiol ,
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PubMed
Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM (2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882.
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PubMed
Molloy EM, Hertweck C (2017) Antimicrobial discovery inspired by ecological interactions. Curr Opin Microbiol 39, 121-127.
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PubMed
Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID (2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617.
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PubMed
Shao Y, Chen B, Sun C, Ishida K, Hertweck C, Boland W (2017) Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota. Cell Chem Biol 24(1), 66-75.
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PubMed
Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA (2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234.
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PubMed PDF Supplement
Barnes EC, Jumpathong J, Lumyong S, Voigt K, Hertweck C (2016) Daldionin, an unprecedented binaphthyl derivative, and diverse polyketide congeners from a fungal orchid endophyte. Chemistry 22(13), 4551-4555.
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PubMed
Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C (2016) Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angew Chem Int Ed 55(39), 11955-11959.
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PubMed
De Felice A, Di Lorenzo F, Scherlach K, Ross C, Silipo A, Hertweck C, Molinaro A (2016) Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061. Carbohydr Res 433, 31-35.
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PubMed
De Felice A, Silipo A, Scherlach K, Ross C, Hertweck C, Molinaro A (2016) Structural and conformational study of the O‐antigenic portion of the Lipopolysaccharide isolated from Burkholderia gladioli pv. cocovenenans. Eur J Org Chem 4, 748-755.
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