Luka Raguž

Chemical Biology of Microbe-Host Interactions · PhD student +49 3641 532-1523 luka.raguz@leibniz-hki.de

Curriculum vitae

Main Research Areas

Synthesis and Derivatisation of Natural Products
Synthetic Method Development
Medicinal Chemistry
Target Identification

Professional Career

2016-	PhD Student Hans-Knöll-Institute
2013-2016	Scientific Assistent in the Research Group of Prof. Riedl (ZHAW)
2011-2013	Master Studies Life Sciences (ZHAW)
2008-20011	Bachelor Studies Chemistry - Zürcher Hochschule für Angewandte Wissenschaften (ZHAW)
2005-2008	Apprenticeship: Chemical Laboratory Assistent

Topics

Natural product synthesis

Publications

Bissell AU, Rautschek J, Hoefgen S, Raguž L, Mattern DJ, Saeed N, Janevska S, Jojić K, Huang Y, Kufs JE, Herboeck B, Guo H, Hillmann F, Beemelmanns C, Valiante V (2022) Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor. ACS Chem Biol 17(2), 386-394.

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Hoefgen S, Bissell AU, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022) Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition. Microbiol Spectr 10(5), e0133122.

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Raguž L, Peng CC, Rutaganira FUN, Krüger T, Stanišić A, Jautzus T, Kries H, Kniemeyer O, Brakhage AA, King N, Beemelmanns C (2022) Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta. Angew Chem Int Ed 61(41), e202209105.

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Brand M, Wang L, Agnello S, Gazzola S, Gall FM, Raguž L, Kaiser M, Schmidt RS, Ritschl A, Jelk J, Hemphill A, Mäser P, Bütikofer P, Adams M, Riedl R (2021) Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angew Chem Int Ed 60(28), 15613-15621.

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Leichnitz D, Peng CC, Raguž L, Rutaganira FUN, Jautzus T, Regestein L, King N, Beemelmanns C (2021) Structural and functional analysis of bacterial sulfonosphingolipids and rosette-inducing factor 2 (RIF-2) by mass spectrometry-guided isolation and total synthesis. Chemistry 28(8), e202103883.

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Raguž L, Peng CC, Kaiser M, Görls H, Beemelmanns C^* (2021) A modular approach to the antifungal Sphingofungin family: Concise total synthesis of Sphingofungin A and C. Angew Chem Int Ed 61(5), e202112616.

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Roman D, Raguž L, Keiff F, Meyer F, Barthels F, Schirmeister T, Kloss F, Beemelmanns C (2020) Modular solid-phase synthesis of antiprotozoal barnesin derivatives. Org Lett 22(10), 3744-3748.

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Raguz L, Beemelmanns C (2019) Ursprung und Funktionen der Sphingolipide. Nachrichten aus der Chemie 67(2), 66-70. (Review)

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Guo H, Schmidt A, Stephan P, Raguž L, Braga D, Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem 19(21), 2307-2311.

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Rischer M, Raguz L, Guo H, Keiff F, Diekert G, Goris T, Beemelmanns C (2018) Biosynthesis, synthesis and activities of barnesin A, a NRPS-PKS hybrid produced by an anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995.

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